Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837075 | 0.79 | TSHR (0.51) | ALDH1A1HSD17B3TSHRMAPTMEN1 | |
| SCHEMBL8590940 | 0.79 | TSHR (0.69) | ALDH1A1GAATSHRMAPTMEN1 | |
| SCHEMBL2087233 | 0.77 | SMN1; SMN2 (0.62) | ALDH1A1GAATSHRNOTUMPOLB | |
| SCHEMBL3266328 | 0.72 | ALDH1A1 (0.66) | ALDH1A1GAATSHRMAPTMEN1 | |
| SCHEMBL24335153 | 0.71 | CASP3 (0.68) | ALDH1A1GAAMEN1KMT2ALMNA | |
| SCHEMBL29530623 | 0.71 | CASP3 (0.68) | ALDH1A1GAAMEN1KMT2ALMNA | |
| SCHEMBL19404981 | 0.70 | HSD17B3 (0.64) | ALDH1A1HSD17B3TSHRMAPTMEN1 | |
| SCHEMBL2088147 | 0.70 | ALDH1A1 (0.62) | ALDH1A1GAATSHRMAPTMEN1 | |
| SCHEMBL24201501 | 0.69 | HSD17B3 (0.67) | ALDH1A1HSD17B3TSHRMAPTMEN1 | |
| SCHEMBL8560249 | 0.69 | HPGD (0.53) | ALDH1A1HSD17B3TSHRKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740171-B1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-09 | — | — | EP | disclosed |