Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840650 | 0.80 | PTGER2 (0.50) | TSHRMAPTKMT2AMEN1HSD17B3 | |
| SCHEMBL4637311 | 0.79 | TSHR (0.81) | TSHRMAPTKMT2AMEN1NOTUM | |
| SCHEMBL3270957 | 0.79 | ALDH1A1 (0.46) | TSHRMAPTKMT2AMEN1HSD17B3 | |
| SCHEMBL5251752 | 0.77 | TSHR (0.67) | TSHRMAPTKMT2AMEN1NOTUM | |
| SCHEMBL24817140 | 0.76 | NOTUM (0.52) | TSHRMAPTKMT2AMEN1NOTUM | |
| SCHEMBL29987139 | 0.76 | NOTUM (0.52) | TSHRMAPTKMT2AMEN1NOTUM | |
| SCHEMBL19404981 | 0.75 | HSD17B3 (0.64) | TSHRMAPTKMT2AMEN1HSD17B3 | |
| SCHEMBL24201501 | 0.74 | HSD17B3 (0.67) | TSHRMAPTKMT2AMEN1HSD17B3 | |
| SCHEMBL8558342 | 0.73 | HPGD (0.48) | KMT2AHSD17B3NPC1RAB9AALDH1A1 | |
| SCHEMBL19014017 | 0.73 | HSD17B3 (0.60) | TSHRMAPTKMT2AMEN1HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820450-B1 | N-substituted azaheterocyclic carboxylic acids and alkylesters thereof | NOVO NORDISK AS (DK) | 2001-09-12 | — | — | EP | disclosed |
| EP-0820450-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031497-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |