Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274461 | 0.88 | PDE10A (0.52) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL3271474 | 0.84 | GPBAR1 (0.67) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL3272300 | 0.83 | ALOX5 (0.50) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL1695312 | 0.82 | PDE10A (0.73) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL3276255 | 0.81 | GPBAR1 (0.53) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL3275859 | 0.79 | ALOX5 (0.55) | PDE10ACYSLTR1GPBAR1ALOX5 | |
| SCHEMBL9430587 | 0.77 | ALOX5 (0.50) | PDE10ACYSLTR1ALOX5 | |
| SCHEMBL3275392 | 0.76 | PDE10A (0.48) | PDE10ACYSLTR1GPBAR1ALOX5 | |
| SCHEMBL9031804 | 0.75 | FFAR1 (0.55) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9581750 | 0.74 | ALOX5 (0.60) | PDE10ACYSLTR1GPBAR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825254-B2 | Heteroaromatic quinoline compounds | PFIZER INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1841757-B1 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | PFIZER PROD INC (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7429665-B2 | Heteroaromatic quinoline compounds | PFIZER INC (US) | 2008-09-30 | — | — | US | disclosed |
| US-20080214607-A1 | HETEROAROMATIC QUINOLINE COMPOUNDS | PFIZER INC | 2008-09-04 | — | — | US | disclosed |
| EP-1841757-A2 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | Pfizer Products Incorporated (US) | 2007-10-10 | — | — | EP | disclosed |
| US-20060154931-A1 | Heteroaromatic quinoline compounds | PFIZER INC | 2006-07-13 | — | — | US | disclosed |
| WO-2006072828-A2 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154931-A1 | Heteroaromatic quinoline compounds | PDE12, PDE7A, PDE4A | PDE10A 8/4885CYSLTR1 2546/4885GPBAR1 1904/4885 |
| US-20080214607-A1 | HETEROAROMATIC QUINOLINE COMPOUNDS | PDE12, PDE7A, PDE4A | PDE10A 8/4885CYSLTR1 2546/4885GPBAR1 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.