Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277469 | 0.89 | ALDH1A1 (0.49) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3271784 | 0.88 | LMNA (0.48) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6268130 | 0.86 | ALDH1A1 (0.42) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3270606 | 0.85 | HRH3 (0.47) | LMNAALDH1A1SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL3270444 | 0.84 | HRH3 (0.60) | LMNAALDH1A1CYP1A2HRH3 | |
| SCHEMBL4837392 | 0.84 | ALDH1A1 (0.41) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3271881 | 0.83 | HRH3 (0.47) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3271106 | 0.83 | HRH3 (0.64) | LMNAALDH1A1CYP1A2HRH3 | |
| SCHEMBL3277540 | 0.82 | HRH3 (0.66) | LMNAALDH1A1CYP1A2HRH3 | |
| SCHEMBL4837404 | 0.82 | LMNA (0.40) | LMNAALDH1A1SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747210-B1 | 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS | WARNER LAMBERT CO (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7456164-B2 | Useful for treatment of H3-related diseases such as neurologic disorders, or inflammatory, respiratory and allergic diseases, disorders and conditions; for example, 4-[4-(1-isopropylpiperidin-4-yloxy)phenyl]tetrahydropyran-4-carbonitrile; well absorbed from gastrointestinal tract, metabolically stable | PFIZER, INC (US) | 2008-11-25 | — | — | US | disclosed |
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | ZIARCO INC. | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267095-A1 | 3- or 4-monosubstituted phenol and thiophenol derivatives useful as H3 ligands | HRH4, HRH3, TLR4 | LMNA 4730/4885ALDH1A1 832/4885SLC6A4 2629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.