SCHEMBL3271784

SCHEMBL3271784

CCCOc1ccc(C2(CN(C)C)CCOCC2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.48
ALDH1A1 P00352 3/20 0.48
CYP1A2 P05177 2/20 0.47
RAB9A P51151 2/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
MAPT P10636 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TSHR P16473 1/20 0.44
SLC6A4 P31645 10/20 0.43
SLC6A3 Q01959 10/20 0.43
SLC6A2 P23975 5/20 0.42
MAPK1 P28482 2/20 0.40
HRH3 Q9Y5N1 2/20 0.40
CHRM2 P08172 1/20 0.40
CHRM1 P11229 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3277469 0.88 ALDH1A1 (0.49) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL3271437 0.88 LMNA (0.45) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL6268130 0.88 ALDH1A1 (0.42) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL3270606 0.86 HRH3 (0.47) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL3271078 0.82 ALDH1A1 (0.51) LMNAALDH1A1HTTSMN1; SMN2SLC6A4
SCHEMBL4837392 0.82 ALDH1A1 (0.41) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL3276000 0.82 HRH3 (0.56) HRH3
SCHEMBL3270444 0.82 HRH3 (0.60) LMNAALDH1A1CYP1A2TSHRMAPK1
SCHEMBL3271881 0.81 HRH3 (0.47) LMNAALDH1A1CYP1A2RAB9ACYP3A4
SCHEMBL3271106 0.81 HRH3 (0.64) LMNAALDH1A1CYP1A2MAPK1HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1747210-B1 3- OR 4-MONOSUBSTITUTED PHENOL AND THIOPHENOL DERIVATIVES USEFUL AS H3 LIGANDS WARNER LAMBERT CO (US) 2010-06-30 EP disclosed