Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213848 | 0.93 | DYRK1A (0.42) | DYRK1ADYRK2DYRK1BDYRK3LMNA | |
| SCHEMBL2212260 | 0.83 | LMNA (0.40) | LMNAHTTDGAT2MEN1KMT2A | |
| SCHEMBL3377133 | 0.83 | MEN1 (0.39) | LMNADGAT2MEN1KMT2ACNR2 | |
| SCHEMBL303432 | 0.82 | LMNA (0.42) | LMNAHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL303301 | 0.80 | MEN1 (0.41) | LMNAHTTMEN1KMT2ACNR2 | |
| SCHEMBL2211916 | 0.80 | MEN1 (0.42) | LMNAMEN1KMT2ACNR2ALDH1A1 | |
| SCHEMBL304312 | 0.79 | KMT2A (0.40) | LMNAMEN1KMT2AALDH1A1GAA | |
| SCHEMBL2214180 | 0.77 | MEN1 (0.54) | LMNAMEN1KMT2ACNR2ALDH1A1 | |
| SCHEMBL2214837 | 0.76 | MEN1 (0.44) | MEN1KMT2AALDH1A1BACE1 | |
| SCHEMBL303882 | 0.76 | KMT2A (0.40) | LMNAHTTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |