Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 12/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347809 | 0.87 | MTNR1A (0.49) | MTNR1AMTNR1BPPARGPTGESALOX5 | |
| SCHEMBL5679220 | 0.85 | MTNR1A (0.51) | MTNR1AMTNR1BPPARGPPARAPPARD | |
| SCHEMBL271643 | 0.84 | MAPT (0.44) | MTNR1AMTNR1BPPARGPTGESALOX5 | |
| SCHEMBL31351913 | 0.84 | MAPT (0.44) | MTNR1AMTNR1BPPARGPTGESALOX5 | |
| SCHEMBL27621116 | 0.84 | HTT (0.51) | MTNR1AMTNR1BPPARGPTGESALOX5 | |
| SCHEMBL320958 | 0.81 | PPARG (0.47) | MTNR1AMTNR1BPPARGPPARAPPARD | |
| SCHEMBL278422 | 0.81 | MAPT (0.44) | MTNR1AMTNR1BPPARGPPARAPPARD | |
| SCHEMBL8560597 | 0.80 | MAPT (0.49) | KDM4EMEN1USP2ALDH1A1TP53 | |
| SCHEMBL8413308 | 0.79 | ADRB2 (0.55) | MTNR1AMTNR1BPPARGPPARAPPARD | |
| SCHEMBL10607537 | 0.79 | HTR1A (0.41) | MTNR1AMTNR1BMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133898-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-13 | — | — | US | disclosed |