Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578921 | 0.85 | GRM5 (0.58) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23389973 | 0.81 | GRM5 (0.49) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL29110703 | 0.80 | ALDH1A1 (0.40) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4871735 | 0.78 | GRM5 (0.54) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13162457 | 0.76 | P2RX7 (0.43) | GRM5 | |
| SCHEMBL13162466 | 0.75 | BRD4 (0.47) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL13162467 | 0.75 | CYP1A2 (0.64) | GRM5NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL23075939 | 0.74 | GRM5 (0.62) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4710493 | 0.73 | GRM5 (0.60) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3274122 | 0.72 | GRM5 (0.60) | GRM5NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691865-B2 | Pyrazolopyridines and methods of making and using the same | BIOGEN IDEC MA INC. (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1551398-A4 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060106033-A1 | Pyrazolopyridines and methods of making and using the same | BIOGEN IDEC MA INC. | 2006-05-18 | — | — | US | disclosed |
| EP-1551398-A1 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004022054-A1 | PYRAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106033-A1 | Pyrazolopyridines and methods of making and using the same | ALK, ACVR1, ACVRL1 | GRM5 2102/4885NPC1 3220/4885RAB9A 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.