Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273681 | 1.00 | PTPN1 (0.45) | PTPN1TRPM2HCAR2TRPA1TRPM8 | |
| SCHEMBL3279060 | 0.89 | HCAR2 (0.47) | TRPM2HCAR2TRPA1TRPM8MAPT | |
| SCHEMBL3279047 | 0.89 | HCAR2 (0.47) | TRPM2HCAR2TRPA1TRPM8MAPT | |
| SCHEMBL3273782 | 0.88 | EGFR (0.47) | PTPN1HCAR2TRPA1MAPTLMNA | |
| SCHEMBL3273777 | 0.88 | EGFR (0.47) | PTPN1HCAR2TRPA1MAPTLMNA | |
| SCHEMBL3272677 | 0.82 | EGFR (0.44) | PTPN1HCAR2TRPA1MAPTLMNA | |
| SCHEMBL3272673 | 0.82 | EGFR (0.44) | PTPN1HCAR2TRPA1MAPTLMNA | |
| SCHEMBL3272544 | 0.82 | KDM4E (0.52) | TRPM2MAPTLMNAKDM4EMEN1 | |
| SCHEMBL3272537 | 0.82 | KDM4E (0.52) | TRPM2MAPTLMNAKDM4EMEN1 | |
| SCHEMBL3278115 | 0.80 | KCNMA1 (0.44) | TRPM2TRPA1TRPM8MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | claimed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | PTPN1 4654/4885TRPM2 5/4885HCAR2 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.