Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13382878 | 0.74 | AR (0.34) | MAPT | |
| SCHEMBL13382786 | 0.71 | ALDH1A1 (0.45) | MAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL23923776 | 0.71 | ALDH1A1 (0.43) | MAPK14RAF1MAPTXDHCYP3A4 | |
| SCHEMBL22397177 | 0.70 | KDM4C (0.41) | MAPTRAB9ACSNK2A2KDRCSNK2B | |
| SCHEMBL28618724 | 0.70 | CYP1A2 (0.52) | MAPTRAB9AXDHCYP3A4ACHE | |
| SCHEMBL2201771 | 0.69 | CA12 (0.43) | MAPTNPC1RAB9AKDRCYP3A4 | |
| SCHEMBL7517428 | 0.69 | NOTUM (0.55) | MAPTNPC1RAB9AXDHATM | |
| SCHEMBL20046200 | 0.69 | CA1 (0.43) | MAPTNPC1RAB9ACYP1A2ATM | |
| SCHEMBL30007012 | 0.69 | CA12 (0.43) | MAPTNPC1RAB9AKDRCYP3A4 | |
| SCHEMBL3023269 | 0.68 | KDM4E (0.50) | MAPTNPC1RAB9ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691896-B2 | Analogs of salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| US-7691896-B2 | Analogs of salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1931679-A4 | ANALOGS OF SALINOSPORAMIDE A | HARVARD COLLEGE (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090054665-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-26 | — | — | US | disclosed |
| US-20090054665-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-26 | — | — | US | disclosed |
| EP-1931679-A1 | ANALOGS OF SALINOSPORAMIDE A | The President and Fellows of Harvard College (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021897-A1 | ANALOGS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054665-A1 | ANALOGS OF SALINOSPORAMIDE A | PSME1, PSMG3, PSMD5 | MAPK14 2060/4885RAF1 1851/4885MAPT 3047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.