Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.49 |
| ▸ | MMP1 | P03956 | 6/20 | 0.47 |
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274105 | 1.00 | PTGES2 (0.49) | PTGES2MMP1MMP2MMP9CA12 | |
| SCHEMBL3272916 | 0.81 | MMP1 (0.49) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3272911 | 0.81 | MMP1 (0.49) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL27885246 | 0.77 | MMP1 (0.71) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3280709 | 0.76 | EGFR (0.50) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3280717 | 0.76 | EGFR (0.50) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3273286 | 0.73 | MMP1 (0.59) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3273292 | 0.73 | MMP1 (0.59) | MMP1MMP2MMP9HCAR2MAOA | |
| SCHEMBL3273877 | 0.73 | MAPT (0.50) | MMP1MMP2MMP9HCAR2KDM1A | |
| SCHEMBL3273883 | 0.73 | MAPT (0.50) | MMP1MMP2MMP9HCAR2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | claimed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| EP-2121569-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | PTGES2 2546/4885MMP1 4839/4885MMP2 4689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.