Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.40 |
| ▸ | CA7 | P43166 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274365 | 0.81 | SMN1; SMN2 (0.46) | ALDH1A1LMNASMN1; SMN2CA12CA14 | |
| SCHEMBL1338381 | 0.79 | CYP19A1 (0.54) | ALDH1A1LMNASMN1; SMN2CA12CA14 | |
| SCHEMBL3274018 | 0.76 | CA12 (0.39) | ALDH1A1SMN1; SMN2CA12CA14CA7 | |
| SCHEMBL1337452 | 0.75 | TRPV4 (0.47) | ALDH1A1LMNASMN1; SMN2TRPV4DDR1 | |
| SCHEMBL8409523 | 0.72 | POLB (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4712224 | 0.72 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL30309668 | 0.71 | TRPV4 (0.50) | ALDH1A1TRPV4BRPF1BRD1BRPF3 | |
| SCHEMBL20743464 | 0.71 | TRPV4 (0.50) | ALDH1A1TRPV4BRPF1BRD1BRPF3 | |
| SCHEMBL4709273 | 0.71 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL1336491 | 0.70 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087491-A1 | POLYCYCLIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-08 | — | — | US | disclosed |
| EP-2081916-A1 | OXADIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE PROPERTIES | Novartis AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008037476-A1 | OXADIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE PROPERTIES | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087491-A1 | POLYCYCLIC COMPOUNDS | CD4, HLA-DRB1, MALT1 | ALDH1A1 1060/4885LMNA 3650/4885SMN1; SMN2 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.