SCHEMBL3274618

SCHEMBL3274618

COc1ccc(O)c(-n2nc3cc(Cl)c(Cl)cc3n2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.45
RAB9A P51151 5/20 0.45
LMNA P02545 1/20 0.45
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
MAPT P10636 4/20 0.40
GAA P10253 3/20 0.40
KDM4E B2RXH2 3/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
ALDH1A1 P00352 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
THRB P10828 1/20 0.40
RECQL P46063 1/20 0.40
BLM P54132 1/20 0.40
MCL1 Q07820 1/20 0.40
HTT P42858 2/20 0.38
ERN1 O75460 1/20 0.38
TRIM24 O15164 1/20 0.38
TYR P14679 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29768260 0.84 RAB9A (0.64) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL563559 0.84 RAB9A (0.64) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL11592476 0.84 NPC1 (0.46) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL564179 0.82 RAB9A (0.61) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL29814623 0.82 RAB9A (0.61) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL561850 0.80 NPC1 (0.71) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL29813507 0.80 NPC1 (0.71) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL6941182 0.79 RAB9A (0.66) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL6927141 0.78 MEN1 (0.54) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL24089236 0.78 HPGD (0.50) NPC1RAB9ALMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1052223-B1 HYDROTALCITE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL FILM CONTAINING THE SAME KYOWA CHEM IND CO LTD (JP) 2010-06-16 EP disclosed
EP-0976681-B1 Novel fine particulate synthetic chalcoalumite compounds, process for their production, and heat insulator and agricultural film containing the fine particulate synthetic chalcoalumite compounds KYOWA CHEM IND CO LTD (JP) 2003-04-02 EP disclosed
US-6418661-B1 RADIATION ABSORBER; AGRICULTURE KYOWA CHEMICAL INDUSTRY CO LTD (JP) 2002-07-16 US disclosed
US-6306494-B1 USED FOR GREENHOUSE CULTIVATION OR TUNNEL CULTIVATION OF AGRICULTURAL PRODUCTS; ULTRAVIOLET AND VISIBLE LIGHT TRANSMISSION, MECHANICAL STRENGTH AND ELONGATION KYOWA CHEMICAL INDUSTRY CO LTD (JP) 2001-10-23 US disclosed
EP-1052223-A1 HYDROTALCITE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND AGRICULTURAL FILM CONTAINING THE SAME Kyowa Chemical Industry Co., Ltd. (JP) 2000-11-15 EP disclosed
EP-0976681-A2 Novel fine particulate synthetic chalcoalumite compounds, process for their production, and heat insulator and agricultural film containing the fine particulate synthetic chalcoalumite compounds KYOWA CHEMICAL INDUSTRY CO., LTD. (JP) 2000-02-02 EP disclosed