Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176557 | 0.92 | CYP19A1 (0.85) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8700549 | 0.80 | CYP19A1 (0.66) | CYP19A1TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL4088048 | 0.80 | CYP19A1 (0.70) | CYP19A1TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL2912058 | 0.78 | CYP19A1 (0.64) | CYP19A1HPGD | |
| SCHEMBL2912464 | 0.78 | CYP19A1 (0.64) | CYP19A1TSHRMAPK1HIF1ATDP1 | |
| Hydrochloric Acid SCHEMBL7782034 | 0.77 | CYP19A1 (0.67) | CYP19A1TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL10674497 | 0.77 | CYP19A1 (1.00) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| Bromide SCHEMBL5873324 | 0.77 | CYP19A1 (0.62) | CYP19A1TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL8028167 | 0.76 | SLC6A2 (0.64) | CYP19A1CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11538836 | 0.76 | CYP19A1 (1.00) | CYP19A1TSHRMAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516278-A1 | Use of anti-mullerian hormone for reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | claimed |
| EP-0514015-A1 | Control of sex differentiation in fish | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | claimed |
| US-5162337-A | Administering Steroid Biosynthesis Inhibitors | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | claimed |
| EP-0479570-A2 | Animal growth promotion with aromatase inhibitors | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | claimed |
| EP-0433084-A2 | Use of aromatese inhibitors for the reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | claimed |
| US-4762836-A | PYRIMIDINE DERIVATIVES, TREATMENT OF BREAST CANCER | ELI LILLY AND COMPANY (US) | 1988-08-09 | — | — | US | claimed |
| EP-0116431-B1 | AROMATASE INHIBITING PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-06-10 | — | — | EP | claimed |
| EP-0116431-A1 | Aromatase inhibiting pyrimidine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | claimed |
| US-20140080794-A1 | Methods and Compositions for the Treatment of Estrogen-Dependent Hyperproliferative Uterine Disorders | VIVUS INC (US) | 2014-03-20 | — | — | US | disclosed |
| US-20100087402-A1 | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders | VIVUS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| EP-0516278-A1 | Use of anti-mullerian hormone for reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0514015-A1 | Control of sex differentiation in fish | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5162337-A | Administering Steroid Biosynthesis Inhibitors | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0479570-A2 | Animal growth promotion with aromatase inhibitors | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| EP-0433084-A2 | Use of aromatese inhibitors for the reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4762836-A | PYRIMIDINE DERIVATIVES, TREATMENT OF BREAST CANCER | ELI LILLY AND COMPANY (US) | 1988-08-09 | — | — | US | disclosed |
| EP-0116431-B1 | AROMATASE INHIBITING PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-06-10 | — | — | EP | disclosed |
| EP-0116431-A1 | Aromatase inhibiting pyrimidine derivatives | ELI LILLY AND COMPANY (US) | 1984-08-22 | — | — | EP | disclosed |