Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276282 | 1.00 | KMT2A (0.48) | KMT2AMEN1SCN4ASMN1; SMN2NPC1 | |
| SCHEMBL5836448 | 1.00 | KMT2A (0.48) | KMT2AMEN1SCN4ASMN1; SMN2NPC1 | |
| SCHEMBL5835521 | 1.00 | KMT2A (0.48) | KMT2AMEN1SCN4ASMN1; SMN2NPC1 | |
| SCHEMBL12946543 | 0.91 | SCN4A (0.45) | KMT2AMEN1SCN4ASMN1; SMN2NPC1 | |
| SCHEMBL14232790 | 0.86 | CASP1 (0.43) | CASP1CASP3CASP8POLB | |
| SCHEMBL3470615 | 0.86 | KLK7 (0.56) | KMT2AMEN1SMN1; SMN2NPC1LMNA | |
| SCHEMBL4460008 | 0.86 | KLK7 (0.56) | KMT2AMEN1SMN1; SMN2NPC1LMNA | |
| SCHEMBL14209492 | 0.86 | CASP1 (0.43) | CASP1CASP3CASP8POLB | |
| SCHEMBL13928556 | 0.86 | CASP1 (0.43) | CASP1CASP3CASP8POLB | |
| SCHEMBL3470091 | 0.86 | CASP1 (0.43) | CASP1CASP3CASP8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278737-B1 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | VERTEX PHARMA (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7109357-B2 | Process and intermediates for making substituted aspartic acid acetals | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-09-19 | — | — | US | disclosed |
| US-20030119899-A1 | Process and intermediates for making substituted aspartic acid acetals | VERTEX PHARMACEUTICALS INCORPORATED | 2003-06-26 | — | — | US | disclosed |
| EP-1278737-A2 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | Vertex Pharmaceuticals Incorporated (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081330-A2 | PROCESS AND INTERMEDIATES FOR MAKING SUBSTITUTED ASPARTIC ACID ACETALS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119899-A1 | Process and intermediates for making substituted aspartic acid acetals | CASP1, CASP4, CASP2 | KMT2A 2846/4885MEN1 2207/4885SCN4A 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.