Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.74 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.58 |
| ▸ | CA1 | P00915 | 5/20 | 0.58 |
| ▸ | CA2 | P00918 | 5/20 | 0.58 |
| ▸ | CA7 | P43166 | 5/20 | 0.58 |
| ▸ | CA9 | Q16790 | 5/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11002386 | 0.92 | KDR (0.82) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL5867039 | 0.90 | KDR (0.74) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL3811573 | 0.88 | KDR (0.76) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL3275816 | 0.87 | LMNA (0.59) | KDRTRPV1PDK1BRAF | |
| SCHEMBL3815898 | 0.87 | KDR (0.74) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL29364392 | 0.86 | KDR (1.00) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL118026 | 0.86 | KDR (1.00) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL16884950 | 0.85 | KDR (0.85) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL11005015 | 0.85 | KDR (0.85) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL3275762 | 0.84 | MAPT (0.60) | KDRCA1CA2CA9MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696249-B2 | Diphenyl urea derivatives | ARPIDA AG (CH) | 2010-04-13 | — | — | US | claimed |
| US-20090005452-A1 | Diphenyl Urea Derivatives | ARIPIDA AG (CH) | 2009-01-01 | — | — | US | claimed |
| CN-101326157-A | Diphenyl urea derivatives | ARPIDA AG (CH) | 2008-12-17 | — | — | CN | claimed |
| EP-1973871-A1 | DIPHENYL UREA DERIVATIVES | Arpida AG (CH) | 2008-10-01 | — | — | EP | claimed |
| WO-2007068395-A1 | DIPHENYL UREA DERIVATIVES | ARPIDA AG (CH) | 2007-06-21 | — | — | WO | claimed |
| US-7696249-B2 | Diphenyl urea derivatives | ARPIDA AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-7696249-B2 | Diphenyl urea derivatives | ARPIDA AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-7696249-B2 | Diphenyl urea derivatives | ARPIDA AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20090005452-A1 | Diphenyl Urea Derivatives | ARIPIDA AG (CH) | 2009-01-01 | — | — | US | disclosed |
| US-20090005452-A1 | Diphenyl Urea Derivatives | ARIPIDA AG (CH) | 2009-01-01 | — | — | US | disclosed |
| US-20090005452-A1 | Diphenyl Urea Derivatives | ARIPIDA AG (CH) | 2009-01-01 | — | — | US | disclosed |
| CN-101326157-A | Diphenyl urea derivatives | ARPIDA AG (CH) | 2008-12-17 | — | — | CN | disclosed |
| EP-1973871-A1 | DIPHENYL UREA DERIVATIVES | Arpida AG (CH) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007068395-A1 | DIPHENYL UREA DERIVATIVES | ARPIDA AG (CH) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005452-A1 | Diphenyl Urea Derivatives | UROD, UGP2, UMPS | KDR 4676/4885TRPV1 3091/4885CA1 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.