Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277116 | 0.90 | PRMT5 (0.54) | ROCK2PRMT5WDR77MAPK1TNIK | |
| SCHEMBL11985664 | 0.84 | PRMT5 (0.49) | ROCK2PRMT5WDR77MAPK1TNIK | |
| SCHEMBL14552616 | 0.82 | MAPK1 (0.47) | ROCK2MAPK1TNIKROCK1AR | |
| SCHEMBL14480961 | 0.82 | SCN1A (0.61) | ROCK2PRMT5WDR77TNIKROCK1 | |
| SCHEMBL14552669 | 0.82 | SCN1A (0.48) | ROCK2ALDH1A1PRMT5WDR77TNIK | |
| SCHEMBL14552578 | 0.81 | TNIK (0.48) | ROCK2MAPK1TNIKROCK1SCN1A | |
| SCHEMBL1671236 | 0.81 | AR (0.47) | ALDH1A1ALDH2ALDH3A1MAPTTSHR | |
| SCHEMBL14552644 | 0.80 | ROCK2 (0.48) | ROCK2ALDH1A1MAPK1TNIKMAPT | |
| SCHEMBL14552648 | 0.79 | MAPK1 (0.40) | ROCK2ALDH1A1ALDH2ALDH3A1PRMT5 | |
| SCHEMBL14481483 | 0.78 | ROCK2 (0.63) | ROCK2MAPK1TNIKROCK1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180064726-A1 | Deuterium-Substituted Oxazepin Compounds | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2018-03-08 | — | — | US | disclosed |
| EP-2123644-B1 | BENZOXAZEPINE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2014-12-17 | — | — | EP | disclosed |
| US-8247403-B2 | Benzoxazepine derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-08-21 | — | — | US | disclosed |
| US-20100087418-A1 | BENZOXAZEPINE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-04-08 | — | — | US | disclosed |
| EP-2123644-A1 | BENZOXAZEPINE DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180064726-A1 | Deuterium-Substituted Oxazepin Compounds | HCN1, KCNN1, CACNA1I | ROCK2 3058/4885ALDH1A1 1671/4885ALDH2 2781/4885 |
| US-20100087418-A1 | BENZOXAZEPINE DERIVATIVES AND USE THEREOF | HTR2C, HTR5A, HTR2B | ROCK2 3276/4885ALDH1A1 324/4885ALDH2 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.