⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10591865 | 0.85 | CHRNA7 (0.31) | — | |
| SCHEMBL4279010 | 0.73 | SLC18A3 (0.35) | — | |
| SCHEMBL7423478 | 0.63 | — | — | |
| SCHEMBL9236734 | 0.62 | — | — | |
| SCHEMBL9550980 | 0.62 | — | — | |
| SCHEMBL3198068 | 0.62 | — | — | |
| SCHEMBL731350 | 0.62 | — | — | |
| SCHEMBL3198076 | 0.62 | — | — | |
| SCHEMBL728782 | 0.62 | — | — | |
| SCHEMBL8340377 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41226-E1 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-04-13 | — | — | US | disclosed |
| US-RE40861-E1 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase | Sigma-Tau Industrie Farmaceutiche Reunite S.p.A. (IT) | 2009-07-21 | — | — | US | disclosed |
| EP-1484313-A1 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2004-12-08 | — | — | EP | disclosed |
| US-6444701-B1 | TREATING HYPERGLYCEMIA, DIABETES AND PATHOLOGIES RELATED THERETO, HEART FAILURE, ISCHEMIA. | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-09-03 | — | — | US | disclosed |
| WO-1999059957-A9 | COMPOUNDS HAVING REVERSIBLE INHIBITING ACTIVITY OF CARNITINE PALMITOYL-TRANSFERASE | SIGMA TAU IND FARMACEUTI (IT) | 2002-06-13 | — | — | WO | disclosed |
| US-20020052348-A1 | Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. | 2002-05-02 | — | — | US | disclosed |
| US-6369073-B1 | HYPERGLYCEMIA, DIABETES, HEART FAILURE, ISCHEMIA | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-04-09 | — | — | US | disclosed |
| EP-1077925-A1 | COMPOUNDS HAVING REVERSIBLE INHIBITING ACTIVITY OF CARNITINE PALMITOYL-TRANSFERASE | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059957-A1 | COMPOUNDS HAVING REVERSIBLE INHIBITING ACTIVITY OF CARNITINE PALMITOYL-TRANSFERASE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1999-11-25 | — | — | WO | disclosed |