Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 2/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754210 | 0.90 | MEN1 (0.35) | MEN1POLBKMT2AS1PR1HTT | |
| SCHEMBL3278248 | 0.87 | MEN1 (0.46) | MEN1POLBKMT2AS1PR1HTT | |
| SCHEMBL3277708 | 0.80 | ACLY (0.32) | ACLYITGA4 | |
| SCHEMBL2055406 | 0.80 | MEN1 (0.33) | MEN1POLBKMT2AS1PR1SMN1; SMN2 | |
| SCHEMBL1754853 | 0.80 | MEN1 (0.35) | MEN1POLBKMT2AS1PR1HTT | |
| SCHEMBL3277898 | 0.77 | S1PR1 (0.40) | MEN1KMT2AS1PR1 | |
| SCHEMBL1753931 | 0.76 | MEN1 (0.45) | MEN1POLBKMT2AS1PR1HTT | |
| SCHEMBL1754851 | 0.76 | MEN1 (0.39) | MEN1POLBKMT2AS1PR1HTT | |
| SCHEMBL3281102 | 0.73 | KDM4E (0.39) | MEN1KMT2AS1PR1HTTNPSR1 | |
| SCHEMBL1754892 | 0.72 | MMP2 (0.39) | MEN1POLBKMT2AS1PR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200987-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009030715-A1 | ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-12 | — | — | WO | disclosed |