Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085333 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2POLBNPC1FLT3CA2 | |
| SCHEMBL11828796 | 0.81 | MAOB (0.65) | SMN1; SMN2POLBCA2MAOAMAOB | |
| SCHEMBL11831412 | 0.81 | CA12 (0.61) | SMN1; SMN2POLBNPC1CA2MAOB | |
| SCHEMBL28212088 | 0.81 | NPC1 (0.57) | SMN1; SMN2POLBNPC1FLT3CA2 | |
| SCHEMBL11578348 | 0.81 | MAOB (0.68) | SMN1; SMN2POLBNPC1CA2MAOB | |
| SCHEMBL7803332 | 0.81 | TYR (0.59) | SMN1; SMN2NPC1FLT3CA2DRD2 | |
| SCHEMBL16284310 | 0.81 | NPC1 (0.57) | SMN1; SMN2POLBNPC1FLT3CA2 | |
| SCHEMBL9479876 | 0.81 | NPC1 (0.57) | SMN1; SMN2POLBNPC1FLT3CA2 | |
| SCHEMBL30550392 | 0.81 | MAOB (0.68) | SMN1; SMN2POLBNPC1CA2MAOB | |
| SCHEMBL30550429 | 0.79 | MAOB (0.66) | SMN1; SMN2POLBNPC1CA2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058277-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| US-8058277-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2011-11-15 | — | — | US | disclosed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |
| US-7700375-B2 | Fluorescent labeling of specific protein targets in vitro and in vivo | VALORISATION-RECHERCHE, LP (CA) | 2010-04-20 | — | — | US | disclosed |
| US-7700375-B2 | Fluorescent labeling of specific protein targets in vitro and in vivo | VALORISATION-RECHERCHE, LP (CA) | 2010-04-20 | — | — | US | disclosed |
| US-7700375-B2 | Fluorescent labeling of specific protein targets in vitro and in vivo | VALORISATION-RECHERCHE, LP (CA) | 2010-04-20 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-20090291963-A1 | SUBSTITUTED INDOLES | SCHADT OLIVER | 2009-11-26 | — | — | US | disclosed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | disclosed |
| US-20060147948-A1 | Fluorescent labeling of specific protein targets in vitro and in vivo | UNIVERSITY OF OTTAWA (CA) | 2006-07-06 | — | — | US | disclosed |
| EP-0816353-B1 | New coumarin derivatives, processes for the preparation thereof and their use | PLIVA PHARM & CHEM WORKS (HR) | 2001-12-19 | — | — | EP | disclosed |
| US-5840922-A | Coumarin derivatives, and processes for their preparation | PLIVA, FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 1998-11-24 | — | — | US | disclosed |
| EP-0816353-A2 | New coumarin derivatives, processes for the preparation thereof and their use | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1998-01-07 | — | — | EP | disclosed |
| EP-0553248-A1 | NOVEL 5-IODO-6-AMINO-1,2-BENZOPYRONES AND THEIR ANALOGS USEFUL AS CYTOSTATIC AND ANTIVIRAL AGENTS. | UNIV CALIFORNIA (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006687-A1 | NOVEL 5-IODO-6-AMINO-1,2-BENZOPYRONES AND THEIR ANALOGS USEFUL AS CYTOSTATIC AND ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054459-A1 | Substituted indoles | TPH2, TPH1, HTR1A | SMN1; SMN2 1396/4885POLB 4047/4885NPC1 1700/4885 |
| US-20090291963-A1 | SUBSTITUTED INDOLES | TPH2, TPH1, HTR1A | SMN1; SMN2 1189/4885POLB 3691/4885NPC1 1674/4885 |
| US-20060147948-A1 | Fluorescent labeling of specific protein targets in vitro and in vivo | QPCTL, MRPL21, STAMBP | SMN1; SMN2 4639/4885POLB 3631/4885NPC1 4005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.