SCHEMBL3277960

SCHEMBL3277960

NNc1ccc(CN2CCOCC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.67
HIF1A Q16665 4/20 0.60
EPAS1 Q99814 4/20 0.60
AOC3 Q16853 1/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
NPC1 O15118 7/20 0.55
RAB9A P51151 6/20 0.55
HTT P42858 1/20 0.55
NOS3 P29474 1/20 0.54
NOS1 P29475 1/20 0.54
NOS2 P35228 1/20 0.54
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
ALDH1A1 P00352 1/20 0.53
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
KCNJ1 P48048 1/20 0.53
NCF1 P14598 1/20 0.51
TP53 P04637 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15467001 0.86 HRH3 (0.87) HRH3HIF1AEPAS1SMN1; SMN2NOS3
SCHEMBL22889633 0.84 HRH3 (0.65) HRH3HIF1AEPAS1SMN1; SMN2NPC1
SCHEMBL5095148 0.84 HRH3 (0.65) HRH3HIF1AEPAS1SMN1; SMN2NPC1
SCHEMBL5993766 0.83 HRH3 (0.69) HRH3SMN1; SMN2ALDH1A1NCF1
SCHEMBL15137345 0.82 SIGMAR1 (0.57) HRH3AOC3HTTMEN1KMT2A
SCHEMBL13946389 0.82 NCF1 (0.65) HRH3HIF1AEPAS1SMN1; SMN2NPC1
SCHEMBL5008349 0.81 ALDH1A1 (0.62) HRH3SMN1; SMN2NPC1RAB9AHTT
SCHEMBL4998852 0.81 HRH3 (0.64) HRH3HIF1AEPAS1AOC3SMN1; SMN2
SCHEMBL60797 0.81 HRH3 (0.71) HRH3HIF1AEPAS1AOC3SMN1; SMN2
SCHEMBL113089 0.81 NCF1 (0.74) HRH3HIF1AEPAS1AOC3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4744651-A2 A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS iOnctura SA (CH) 2026-05-20 EP disclosed
EP-4727554-A1 COMBINATIONS OF IOA-244, A PD-1 OR PD-L1 INHIBITOR AND A CHEMOTHERAPEUTIC AGENT TO TREAT CANCER iOnctura SA (CH) 2026-04-22 EP disclosed
US-12605389-B2 PI3K-δ inhibitor for use in treatment regimens IONCTURA SA (CH) 2026-04-21 US disclosed
EP-4676478-A1 COMBINATION OF ROGINOLISIB AND BCL-2 INHIBITOR IN THE TREATMENT OF HAEMATOLOGICAL MALIGNANCY iOnctura SA (CH) 2026-01-14 EP disclosed
EP-4676454-A1 COMBINATION OF ROGINOLISIB AND HDAC INHIBITOR IN THE TREATMENT OF HAEMATOLOGICAL MALIGNANCY iOnctura SA (CH) 2026-01-14 EP disclosed
CN-115836077-B Oxazaspiro derivative, preparation method thereof and application thereof in medicine 江苏恒瑞医药股份有限公司 2025-05-13 CN disclosed
WO-2025073968-A1 COMBINATION OF ROGINOLISIB WITH A MALT1-GLS INHIBITOR IONCTURA SA (CH) 2025-04-10 WO disclosed
EP-4313058-B1 COMPOSITION COMPRISING ROGINOLISIB AND DOSAGE REGIME FOR TREATING CANCER OR AN INFLAMMATORY OR AUTOIMMUNE DISEASE IONCTURA SA (CH) 2025-03-05 EP disclosed
WO-2024256552-A1 COMBINATIONS OF IOA-244, A PD-1 OR PD-L1 INHIBITOR AND A CHEMOTHERAPEUTIC AGENT TO TREAT CANCER IONCTURA SA (CH) 2024-12-19 WO disclosed
WO-2024184266-A1 COMBINATION OF ROGINOLISIB AND HDAC INHIBITOR IN THE TREATMENT OF HAEMATOLOGICAL MALIGNANCY IONCTURA SA (CH) 2024-09-12 WO disclosed
US-7691888-B2 Thiazolyl-dihydro-indazole BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-06 US disclosed
US-7691888-B2 Thiazolyl-dihydro-indazole BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-06 US disclosed
US-7691888-B2 Thiazolyl-dihydro-indazole BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-04-06 US disclosed
EP-1799690-B1 THIAZOLYL-DIHYDRO INDAZOLES BOEHRINGER INGELHEIM INT (DE) 2008-04-16 EP disclosed
EP-1799690-B1 THIAZOLYL-DIHYDRO INDAZOLES BOEHRINGER INGELHEIM INT (DE) 2008-04-16 EP disclosed
EP-1857446-A1 NOVEL HSP90 INHIBITOR Nippon Kayaku Kabushiki Kaisha (JP) 2007-11-21 EP disclosed
CN-101035795-A Thiazolyl dihydroindazoles BOEHRINGER INGELHEIM INT (DE) 2007-09-12 CN disclosed
EP-1799690-A1 THIAZOLYL-DIHYDRO INDAZOLES Boehringer Ingelheim International GmbH (DE) 2007-06-27 EP disclosed
US-20060100254-A1 N-[1-(3-dimethylamino-4-formyl-phenyl)-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl]-acetamide; phosphatidylinositol-3-kinases (PI3-kinases) inhibitor; cell growth, differentiation and intracellular transport processes; antiproliferative, antiinflammatory agent; autoimmune diseases BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-05-11 US disclosed
WO-2006040281-A1 THIAZOLYL-DIHYDRO INDAZOLES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-04-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060100254-A1 N-[1-(3-dimethylamino-4-formyl-phenyl)-3-pyridin-3-yl-4,5-dihydro-1H-pyrazolo[4,3-g]benzothiazol-7-yl]-acetamide; phosphatidylinositol-3-kinases (PI3-kinases) inhibitor; cell growth, differentiation and intracellular transport processes; antiproliferative, antiinflammatory agent; autoimmune diseases CDK1, MAPK1, NFATC1 HRH3 1999/4885HIF1A 1500/4885EPAS1 926/4885
US-12605389-B2 PI3K-δ inhibitor for use in treatment regimens PIK3CD, PIK3R5, PIK3R4 HRH3 2867/4885HIF1A 3393/4885EPAS1 1113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.