Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3277959 | 0.99 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL2268248 | 0.88 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL503402 | 0.88 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL12590895 | 0.85 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL10349980 | 0.84 | ALDH1A1 (0.58) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL6444094 | 0.83 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL1150661 | 0.83 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL1150660 | 0.83 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL8267137 | 0.83 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL31326042 | 0.82 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586444-B1 | Pharmaceutical formulation of carboxamide HIV integrase inhibitors containing a release rate control composition | MERCK SHARP & DOHME (US) | 2019-09-25 | — | — | EP | disclosed |
| EP-3165220-B1 | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTI-NUCLEATING AGENT | MERCK SHARP & DOHME (US) | 2019-04-03 | — | — | EP | disclosed |
| US-8592436-B2 | Arylamide pyrimidone derivatives | SANOFI (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2148866-B1 | ARYLAMIDE PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI SA (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20100087460-A1 | ARYLAMIDE PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-04-08 | — | — | US | disclosed |
| EP-1992620-A1 | Arylamide pyrimidone derivatives for the treatment of neurodegenerative diseases | Sanofi-Aventis (FR) | 2008-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087460-A1 | ARYLAMIDE PYRIMIDONE DERIVATIVES | DHFR, XDH, HPRT1 | MEN1 1547/4885KMT2A 2609/4885SMN1; SMN2 3258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.