Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799718 | 1.00 | MAOB (0.56) | MAOBMAPTPOLBHSP90AA1ALDH1A1 | |
| SCHEMBL31287823 | 0.84 | MAPT (0.55) | MAOBMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL21359775 | 0.82 | MAOB (0.60) | MAOBMAPTPOLBHSP90AA1ALDH1A1 | |
| SCHEMBL29799834 | 0.82 | MMP2 (0.40) | MAOBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17235692 | 0.82 | MMP2 (0.40) | MAOBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7420394 | 0.82 | LTA4H (0.48) | MAOBMAPTALDH1A1SMN1; SMN2MEN1 | |
| Fluoride SCHEMBL28103700 | 0.80 | LTA4H (0.46) | MAOBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14289677 | 0.79 | MAOB (0.56) | MAOBMAPTPOLBHSP90AA1ALDH1A1 | |
| SCHEMBL19792025 | 0.79 | MAOB (0.56) | MAOBMAPTPOLBHSP90AA1ALDH1A1 | |
| SCHEMBL128748 | 0.79 | MAOB (0.86) | MAOBMAPTPOLBHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11369620-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-11369620-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2022-06-28 | — | — | US | disclosed |
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| US-20200323885-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-10-15 | — | — | US | disclosed |
| US-20200323885-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-10-15 | — | — | US | disclosed |
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-03-24 | — | — | US | disclosed |
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2020-03-24 | — | — | US | disclosed |
| US-20190192541-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2019-06-27 | — | — | US | disclosed |
| US-20190192541-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2019-06-27 | — | — | US | disclosed |
| US-6458803-B1 | COMPOSITIONS AND METHODS FOR TREATING ATHEROSCLEROSIS AND OTHER CORONARY ARTERY DISEASES. PREFERRED TERTIARY-HETEROALKYLAMINE COMPOUNDS ARE SUBSTITUTED N-PHENYL-N-HETEROARALKYL AMINOALCOHOLS. A PREFERRED SPECIFIC | G.D. SEARLE & CO. | 2002-10-01 | — | — | US | disclosed |
| US-6455519-B1 | TREATING ATHEROSCLEROSIS AND CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. | 2002-09-24 | — | — | US | disclosed |
| US-6451830-B1 | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. | 2002-09-17 | — | — | US | disclosed |
| US-6451823-B1 | Use of substituted N-phenoxy-N-phenyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity | G.D. SEARLE & CO. | 2002-09-17 | — | — | US | disclosed |
| US-6448295-B1 | TREATING CARDIOVASCULAR DISEASE; ATHEROSCLEROSIS, DYSLIPIDEMA HYPERCHOLESTEROLAEMIA; DECREASING CONCENTRATIONS OF LOW DENSITY LIPOPROTEIN AND RAISING LEVEL OF HIGH DENSITY LIPOPROTEIN | G.D. SEARLE & CO. | 2002-09-10 | — | — | US | disclosed |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | SIKORSKI JAMES A (US) | 2002-08-29 | — | — | US | disclosed |
| EP-1115693-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | disclosed |
| EP-1115695-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018724-A1 | (R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(n+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000018721-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10596183-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | BTK, BCL9, BCL9L | MAOB 3569/4885MAPT 3298/4885POLB 2226/4885 |
| US-20190192541-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | BTK, BCL9, BCL9L | MAOB 3569/4885MAPT 3298/4885POLB 2226/4885 |
| US-11369620-B2 | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases | BTK, BCL9, BCL9L | MAOB 3569/4885MAPT 3298/4885POLB 2226/4885 |
| US-20020120011-A1 | Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity | CETP, PCTP, DBI | MAOB 1480/4885MAPT 2715/4885POLB 2463/4885 |
| US-20200323885-A1 | Pharmaceutical Compositions and Their Use for Treatment of Cancer and Autoimmune Diseases | BTK, BCL9, BCL9L | MAOB 3569/4885MAPT 3298/4885POLB 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.