Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582750 | 0.89 | KEAP1 (0.56) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL26130407 | 0.89 | KEAP1 (0.56) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL13085444 | 0.86 | KEAP1 (0.91) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL10414143 | 0.84 | KEAP1 (0.76) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL7179616 | 0.82 | KEAP1 (0.74) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL30068740 | 0.82 | KEAP1 (0.74) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL8053648 | 0.81 | KEAP1 (0.71) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL27879953 | 0.80 | KEAP1 (0.70) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL21867305 | 0.80 | KEAP1 (0.48) | KEAP1MAPTPOLBHTTALDH1A1 | |
| SCHEMBL22784496 | 0.79 | NOTUM (0.50) | KEAP1MAPTPOLBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11535597-B2 | Photoreactive ligands and uses thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-12-27 | — | — | US | disclosed |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE | 2020-03-05 | — | — | US | disclosed |
| US-7700794-B2 | Fluorous tagging compounds and methods of increasing the fluorous nature of compounds | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-04-20 | — | — | US | disclosed |
| US-7700794-B2 | Fluorous tagging compounds and methods of increasing the fluorous nature of compounds | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-04-20 | — | — | US | disclosed |
| WO-2009098282-A1 | LOW MOLECULAR WEIGHT 2,5-DISUBSTITUTED THIOPHENE DERIVATIVES AND USE THEREOF IN THERAPY | NOVASAID AB (SE) | 2009-08-13 | — | — | WO | disclosed |
| US-20050096478-A1 | Fluorous tagging compounds and methods of increasing the fluorous nature of compounds | UNIVERSITY OF PITTSBURGH | 2005-05-05 | — | — | US | disclosed |
| US-6825043-B1 | FOR DRUG SCREENING/CATALYST DESIGN | UNIVERSITY OF PITTSBURGH | 2004-11-30 | — | — | US | disclosed |
| EP-1280765-A2 | FLUOROUS TAGGING COMPOUNDS AND THEIR USE | UNIVERSITY OF PITTSBURGH (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085675-A2 | FLUOROUS TAGGING COMPOUNDS AND THEIR USE | UNIVERSITY OF PITTSBURGH (US) | 2001-11-15 | — | — | WO | disclosed |
| US-4945096-A | Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates | SYNTHELABO (FR) | 1990-07-31 | — | — | US | disclosed |
| US-4885302-A | 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy | SYNTHELABO, 58, RUE DE LA GLACIERE - 75013 PARIS | 1989-12-05 | — | — | US | disclosed |
| US-4243666-A | HYPOTENSIVE AGENTS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11535597-B2 | Photoreactive ligands and uses thereof | CLTB, CRYAB, CRYAA | KEAP1 1781/4885MAPT 3004/4885POLB 4131/4885 |
| US-20050096478-A1 | Fluorous tagging compounds and methods of increasing the fluorous nature of compounds | AFF1, AFF2, AFF4 | KEAP1 1999/4885MAPT 4416/4885POLB 2667/4885 |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | CLTB, CRYAB, CRYAA | KEAP1 1781/4885MAPT 3004/4885POLB 4131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.