Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 5/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 8/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14690339 | 0.84 | CSNK1E (0.44) | CSNK1E | |
| SCHEMBL9416071 | 0.73 | CSNK1E (0.54) | CSNK1EDNM1MEN1TP53MAPK1 | |
| Hydrochloric Acid SCHEMBL9342631 | 0.73 | BDKRB2 (0.68) | CSNK1EBDKRB2DNM1MEN1TP53 | |
| SCHEMBL8100368 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL8094331 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL8094075 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL22806767 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL8095039 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL8093074 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 | |
| SCHEMBL8094019 | 0.73 | CSNK1E (0.60) | CSNK1EDNM1MEN1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704752-B2 | Signalling compounds for use in methods of detecting hydrogen peroxide | LUMIGEN, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20080261318-A1 | Signalling Compounds For Use In Methods Of Detecting Hydrogen Peroxide | LUMIGEN, INC. (US) | 2008-10-23 | — | — | US | disclosed |