Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 4/20 | 0.56 |
| ▸ | RHOA | P61586 | 4/20 | 0.56 |
| ▸ | TMPRSS4 | Q9NRS4 | 5/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MYLK | Q15746 | 1/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130511 | 0.88 | TMPRSS4 (0.65) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL16707260 | 0.84 | TMPRSS4 (0.60) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL3282289 | 0.82 | TMPRSS4 (0.75) | RHOCRHOATMPRSS4P2RX1P2RX4 | |
| SCHEMBL6102843 | 0.80 | TMPRSS4 (0.58) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL6103043 | 0.79 | P2RX1 (0.54) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL3497425 | 0.78 | TMPRSS4 (0.64) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL330156 | 0.78 | NR1H4 (0.60) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL4498846 | 0.77 | TMPRSS4 (0.62) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL6103412 | 0.77 | TMPRSS4 (0.54) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL3277394 | 0.77 | PSMB5 (0.50) | TMPRSS4P2RX1P2RX4P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700655-B2 | Antiallergic agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2010-04-20 | — | — | US | disclosed |
| US-20080090779-A1 | ANTIALLERGIC AGENTS | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2008-04-17 | — | — | US | disclosed |
| US-20070185059-A1 | Antiallergic agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2007-08-09 | — | — | US | disclosed |
| US-20070185110-A1 | Antiallergic agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2007-08-09 | — | — | US | disclosed |
| US-20060122243-A1 | Antiallergic | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2006-06-08 | — | — | US | disclosed |
| US-20060111409-A1 | Medicament for treatment of diabetes | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2006-05-25 | — | — | US | disclosed |
| US-20060100257-A1 | Inhibitors against the activation of ap-1 and nfat | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2006-05-11 | — | — | US | disclosed |
| US-20060019958-A1 | Immunity-related protein kinase inhibitors | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2006-01-26 | — | — | US | disclosed |
| EP-1514544-A1 | ANTIALLERGIC | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-16 | — | — | EP | disclosed |
| EP-1512396-A1 | INHIBITORS AGAINST THE ACTIVATION OF AP-1 AND NFAT | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-09 | — | — | EP | disclosed |
| EP-1510207-A1 | THERAPEUTIC DRUG FOR DIABETES | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-02 | — | — | EP | disclosed |
| EP-1510210-A1 | IMMUNITY-RELATED PROTEIN KINASE INHIBITORS | Institute of Medicinal Molecular Design, Inc. (JP) | 2005-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019958-A1 | Immunity-related protein kinase inhibitors | MAP3K1, MAP3K7, MAP3K8 | RHOC 2810/4885RHOA 1520/4885TMPRSS4 3777/4885 |
| US-20060111409-A1 | Medicament for treatment of diabetes | XDH, SLC5A1, SLC5A2 | RHOC 4799/4885RHOA 3677/4885TMPRSS4 3657/4885 |
| US-20080090779-A1 | ANTIALLERGIC AGENTS | NAT1, EPX, HRH2 | RHOC 4593/4885RHOA 2455/4885TMPRSS4 4322/4885 |
| US-20060122243-A1 | Antiallergic | EPX, NAT1, HNMT | RHOC 4591/4885RHOA 2412/4885TMPRSS4 4304/4885 |
| US-20060100257-A1 | Inhibitors against the activation of ap-1 and nfat | NFATC1, AP1G1, ATF1 | RHOC 4317/4885RHOA 1237/4885TMPRSS4 3386/4885 |
| US-20070185110-A1 | Antiallergic agents | NAT1, EPX, AHR | RHOC 4625/4885RHOA 2590/4885TMPRSS4 4402/4885 |
| US-20070185059-A1 | Antiallergic agents | NAT1, EPX, AHR | RHOC 4617/4885RHOA 2658/4885TMPRSS4 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.