Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 9/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10126587 | 0.91 | XDH (0.39) | XDHGFERRXFP1SLC22A12JAK2 | |
| SCHEMBL10156468 | 0.83 | XDH (0.39) | XDHGFERRXFP1SLC22A12JAK2 | |
| SCHEMBL10126474 | 0.80 | XDH (0.43) | XDHGFERRXFP1SLC22A12ALDH1A1 | |
| SCHEMBL10156543 | 0.78 | SYK (0.40) | GFERKDM4EGAAPTK2KLK7 | |
| SCHEMBL10156479 | 0.78 | XDH (0.41) | XDHGFERRXFP1SLC22A12 | |
| SCHEMBL10156488 | 0.78 | XDH (0.41) | XDHGFERRXFP1SLC22A12 | |
| SCHEMBL10155939 | 0.78 | XDH (0.39) | XDHGFERRXFP1SLC22A12LMNA | |
| SCHEMBL10126584 | 0.74 | JAK2 (0.45) | JAK2JAK1 | |
| SCHEMBL282772 | 0.73 | GFER (0.43) | XDHGFERRXFP1 | |
| SCHEMBL10126531 | 0.73 | ALDH1A1 (0.42) | XDHGFERRXFP1SLC22A12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2012-03-14 | — | — | EP | disclosed |