Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 18/20 | 0.39 |
| ▸ | PDE4A | P27815 | 11/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671145 | 0.75 | PDE3B (0.53) | PDE3APDE3BALDH1A1 | |
| SCHEMBL6403354 | 0.71 | MCHR1 (0.45) | CREBBP | |
| SCHEMBL15427070 | 0.66 | PDE3B (0.45) | PDE3APDE3BALDH1A1LMNAMAPT | |
| SCHEMBL3282933 | 0.66 | PDE4A (0.34) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL293099 | 0.64 | PDE3B (0.77) | PDE3APDE3BALDH1A1 | |
| SCHEMBL27521810 | 0.64 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL3282936 | 0.63 | ALDH1A1 (0.41) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6907670 | 0.62 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL30775216 | 0.62 | ALDH1A1 (0.47) | PDE3APDE3BCYP3A4ALDH1A1LMNA | |
| SCHEMBL3261887 | 0.62 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696214-B2 | Quinazoline derivatives for the treatment of tumours | ASTRAZENECA AB (SE) | 2010-04-13 | — | — | US | disclosed |
| US-20060258642-A1 | Quinazoline derivatives for the treatment of tumours | ASTRAZENECA AB | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258642-A1 | Quinazoline derivatives for the treatment of tumours | TPD52L2, NQO2, H1-5 | PDE3A 646/4885PDE3B 765/4885PDE4B 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.