Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.47 |
| ▸ | THRA | P10827 | 15/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156775 | 0.82 | THRA (0.53) | THRBTHRA | |
| SCHEMBL13381681 | 0.81 | THRA (0.47) | THRBTHRA | |
| SCHEMBL281980 | 0.75 | THRA (0.41) | THRBTHRA | |
| SCHEMBL23462762 | 0.69 | THRB (0.69) | THRBTHRA | |
| SCHEMBL21565924 | 0.68 | THRA (0.53) | THRBTHRA | |
| SCHEMBL21286536 | 0.68 | THRB (0.76) | THRBTHRA | |
| SCHEMBL27713138 | 0.66 | THRB (0.41) | THRBTHRADHFRGABRA1GABRB1 | |
| SCHEMBL24632149 | 0.65 | THRB (0.71) | THRBTHRA | |
| SCHEMBL4603030 | 0.65 | GABRA1 (0.53) | THRBTHRADHFRGABRA1GABRB1 | |
| SCHEMBL24132760 | 0.64 | THRA (0.69) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |