Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15597016 | 0.93 | LTA4H (0.44) | MAOBLTA4HTSHRMAPTKMT2A | |
| SCHEMBL15596859 | 0.84 | SMN1; SMN2 (0.46) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL778774 | 0.82 | MAOB (0.44) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL11989262 | 0.78 | MAOB (0.41) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL14997984 | 0.78 | PTGS1 (0.50) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL12653305 | 0.78 | ALDH1A1 (0.42) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL18921230 | 0.77 | MAPT (0.58) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL14959582 | 0.77 | APP (0.40) | MEN1KMT2AALDH1A1GAAPTGS1 | |
| SCHEMBL22559 | 0.76 | LTA4H (0.75) | MAOBLTA4HTSHRMAPTMEN1 | |
| SCHEMBL4025817 | 0.76 | LTA4H (0.75) | MAOBLTA4HTSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |