Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492495 | 0.86 | GPR84 (0.52) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL18923871 | 0.78 | HTR2A (0.61) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL4500910 | 0.78 | MTNR1A (0.62) | HTR2AMTNR1AMTNR1BNR4A2MEN1 | |
| SCHEMBL3284144 | 0.78 | MTNR1A (0.59) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL27428545 | 0.76 | HTR2A (0.49) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL25139531 | 0.76 | HTR2A (0.58) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL3281452 | 0.76 | HTR2A (0.62) | HTR2ANR4A2NR3C1NR3C2PCSK9 | |
| SCHEMBL24460220 | 0.76 | MTNR1A (0.80) | HTR2AMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL27427197 | 0.75 | HTR2A (0.45) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 | |
| SCHEMBL12233833 | 0.73 | HTR2A (0.67) | HTR2AMTNR1AMTNR1BNR4A2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705034-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | disclosed |
| CN-101522615-A | Vinylogous acids derivatives as chymase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-09-02 | — | — | CN | disclosed |
| EP-2074090-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| US-20080096953-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-24 | — | — | US | disclosed |
| WO-2008043698-A1 | VINYLOGOUS ACIDS DERIVATIVES AS CHYMASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096953-A1 | Vinylogous acid derivatives | CMA1, TPSG1, GAA | HTR2A 3360/4885MTNR1A 1303/4885MTNR1B 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.