Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | IRS1 | P35568 | 1/20 | 0.49 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.49 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891825 | 0.92 | AKT1 (0.85) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL328426 | 0.90 | AKT1 (0.82) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891838 | 0.88 | AKT1 (0.79) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891821 | 0.88 | AKT1 (0.78) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891819 | 0.88 | AKT1 (0.78) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11893045 | 0.87 | AKT1 (0.77) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891816 | 0.87 | AKT1 (0.77) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891812 | 0.87 | AKT1 (0.77) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891813 | 0.87 | AKT1 (0.77) | AKT1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11891831 | 0.87 | AKT1 (0.77) | AKT1KMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648255-B2 | Inhibitors for treatment of hematological malignancies | MASARYKOVA UNIVERZITA (CZ) | 2023-05-16 | — | — | US | disclosed |
| US-20220000879-A1 | Inhibitors for Treatment of Hematological Malignancies | MASARYKOVA UNIVERZITA (CZ) | 2022-01-06 | — | — | US | disclosed |
| US-20200396995-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2020-12-24 | — | — | US | disclosed |
| US-10448637-B2 | Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-10-22 | — | — | US | disclosed |
| US-20170311597-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | ARIZONA BOARD OF REGENTS ON BEHALF OF UNIVERSITY OF ARIZONA (US) | 2017-11-02 | — | — | US | disclosed |
| EP-2428504-B1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | UNIV TEXAS (US) | 2017-05-17 | — | — | EP | disclosed |
| US-9320734-B2 | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150126563-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-05-07 | — | — | US | disclosed |
| US-8962663-B2 | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-02-24 | — | — | US | disclosed |
| US-20130184317-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2013-07-18 | — | — | US | disclosed |
| US-8420678-B2 | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-04-16 | — | — | US | disclosed |
| US-20120189670-A1 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. | 2012-07-26 | — | — | US | disclosed |
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20110144066-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-06-16 | — | — | US | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144066-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEKHA1, PLEC | AKT1 92/4885KMT2A 3162/4885MEN1 1607/4885 |
| US-20150126563-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEKHA1, PLEC | AKT1 92/4885KMT2A 3162/4885MEN1 1607/4885 |
| US-20200396995-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | GAB1, GRB2, BCR | AKT1 878/4885KMT2A 1958/4885MEN1 2912/4885 |
| US-20170311597-A1 | INHIBITORS OF GRB2-ASSOCIATED BINDING PROTEIN 1 (GAB1) AND METHODS OF TREATING CANCER USING THE SAME | GAB1, GRB2, BCR | AKT1 1479/4885KMT2A 2240/4885MEN1 3346/4885 |
| US-20130184317-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEKHA1, PLEC | AKT1 92/4885KMT2A 3162/4885MEN1 1607/4885 |
| US-20220000879-A1 | Inhibitors for Treatment of Hematological Malignancies | GAB1, BTK, MCL1 | AKT1 1250/4885KMT2A 457/4885MEN1 1850/4885 |
| US-10448637-B2 | Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same | GAB1, GRB2, BCR | AKT1 1479/4885KMT2A 2240/4885MEN1 3346/4885 |
| US-20120189670-A1 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEC, PLEKHA1 | AKT1 80/4885KMT2A 4375/4885MEN1 955/4885 |
| US-11648255-B2 | Inhibitors for treatment of hematological malignancies | GAB1, BTK, MCL1 | AKT1 1250/4885KMT2A 457/4885MEN1 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.