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Sugi Predict / Targets / PLEKHG3

PLEKHG3

Pleckstrin homology domain-containing family G member 3 · A1L390 · PLEKHG3 on Sugi Atlas →

113 patent compounds predicted against PLEKHG3, 87 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL22024879 SCHEMBL22024879 0.70 1/20
SCHEMBL4698765 SCHEMBL4698765 0.61 1/20
SCHEMBL22024880 SCHEMBL22024880 0.61 1/20
SCHEMBL4700718 SCHEMBL4700718 0.60 1/20
SCHEMBL4699844 SCHEMBL4699844 0.60 1/20
SCHEMBL2806838 SCHEMBL2806838 0.58 1/20
SCHEMBL14070193 SCHEMBL14070193 0.58 1/20
SCHEMBL4697700 SCHEMBL4697700 0.58 1/20
SCHEMBL21943483 SCHEMBL21943483 0.57 1/20
SCHEMBL22025542 SCHEMBL22025542 0.57 1/20
SCHEMBL14070255 SCHEMBL14070255 0.56 1/20
SCHEMBL4697113 SCHEMBL4697113 0.56 1/20
SCHEMBL4699434 SCHEMBL4699434 0.56 1/20
SCHEMBL14069588 SCHEMBL14069588 0.56 1/20
SCHEMBL20558521 SCHEMBL20558521 0.56 1/20
SCHEMBL4697958 SCHEMBL4697958 0.56 1/20
SCHEMBL4754278 SCHEMBL4754278 0.56 1/20
SCHEMBL14069862 SCHEMBL14069862 0.56 1/20
SCHEMBL14069733 SCHEMBL14069733 0.55 1/20
SCHEMBL29728053 SCHEMBL29728053 0.55 1/20

Clinical trials — most relevant to PLEKHG3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pembrolizumab Plus Enfortumab Vedotin in Collecting Duct and Renal Medullary Carcinoma PHASE2RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease. PHASE1COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA nanRECRUITING
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease. nanUNKNOWN
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks nanRECRUITING
PCD New Gene Discovery nanCOMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations nanCOMPLETED
A Family Study of Copy Number Variations in Patients With Autism Spectrum Disorder nanCOMPLETED
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
The Chinese Pulmonary Lymphoepithelioma-like Carcinoma Collaboration Study nanRECRUITING
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease nanUNKNOWN
The Genetic Study of Primary Angle-Closure Glaucoma nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome nanACTIVE_NOT_RECRUITING
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank nanCOMPLETED
Genetic Study of Familial Epilepsy nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome nanCOMPLETED
Rostock International Parkinson's Disease Study (ROPAD) nanCOMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome nanRECRUITING
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PLEKHG3 binder may also engage these)

ProteinNameSimilarity
MAP3K9 Mitogen-activated protein kinase kinase kinase 9 0.997 landscape →
Q8R0S2 — 0.996 Q8R0S2 →
Q9BQI7 — 0.996 Q9BQI7 →
Q60610 — 0.996 Q60610 →
Q4VAC9 — 0.995 Q4VAC9 →
Q6P1I6 — 0.995 Q6P1I6 →
Q9Y2H5 — 0.995 Q9Y2H5 →
Q76N89 — 0.994 Q76N89 →
Q8N4X5 — 0.994 Q8N4X5 →
O70405 — 0.994 O70405 →
Q17R10 — 0.994 Q17R10 →
Q76LL6 — 0.994 Q76LL6 →
Q9QY39 — 0.993 Q9QY39 →
P59808 — 0.993 P59808 →
D4AEC2 — 0.993 D4AEC2 →
Q3U1V8 — 0.992 Q3U1V8 →
O08774 — 0.992 O08774 →
A0A0G2JUG7 — 0.992 A0A0G2JUG7 →
Q9ULL1 — 0.992 Q9ULL1 →
Q9ULJ8 — 0.992 Q9ULJ8 →
Q9D684 — 0.992 Q9D684 →
Q8IX03 — 0.992 Q8IX03 →
B1AZP2 — 0.992 B1AZP2 →
Q76G19 — 0.992 Q76G19 →
Q80Z38 — 0.992 Q80Z38 →
B2RWW0 — 0.992 B2RWW0 →
Q3TES0 — 0.991 Q3TES0 →
A5D794 — 0.991 A5D794 →
Q8K4P8 — 0.991 Q8K4P8 →
Q922B9 — 0.991 Q922B9 →