Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PDE1A | P54750 | 2/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27901420 | 0.92 | DCTPP1 (0.51) | DCTPP1CNR1CNR2NPBWR1NPC1 | |
| SCHEMBL25252708 | 0.88 | PKM (0.48) | DCTPP1SMN1; SMN2MAPTPKMKMT2A | |
| SCHEMBL30491679 | 0.88 | PKM (0.48) | DCTPP1SMN1; SMN2MAPTPKMKMT2A | |
| SCHEMBL2049090 | 0.84 | RECQL (0.53) | CNR1CNR2MAPTKMT2A | |
| SCHEMBL25290375 | 0.84 | RECQL (0.53) | CNR1CNR2MAPTKMT2A | |
| SCHEMBL30491733 | 0.84 | RECQL (0.53) | CNR1CNR2MAPTKMT2A | |
| SCHEMBL25248984 | 0.82 | PKM (0.47) | DCTPP1SMN1; SMN2MAPTPKMHPGD | |
| SCHEMBL5592504 | 0.82 | NOS1 (0.41) | DCTPP1SMN1; SMN2MAPTGRIN1GRIN2B | |
| SCHEMBL25251187 | 0.81 | DCTPP1 (0.44) | DCTPP1NPBWR1PKMPKLRGRIN1 | |
| SCHEMBL31169334 | 0.81 | DCTPP1 (0.44) | DCTPP1NPBWR1PKMPKLRGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-09 | — | — | US | disclosed |
| CN-101796046-A | Pyrimidine derivatives 934 | ASTRAZENECA AB | 2010-08-04 | — | — | CN | disclosed |
| US-7718653-B2 | Pyrimidine derivatives for inhibiting Eph receptors | ASTRAZENECA AB (SE) | 2010-05-18 | — | — | US | disclosed |
| EP-2183242-A2 | PYRIMIDINE DERIVATIVES 934 | AstraZeneca AB (SE) | 2010-05-12 | — | — | EP | disclosed |
| US-20090023719-A1 | PYRIMIDINE DERIVATIVES 934 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | disclosed |
| WO-2009010789-A2 | PYRIMIDINE DERIVATIVES 934 | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023719-A1 | PYRIMIDINE DERIVATIVES 934 | EPHB4, EPHA2, EPHB1 | DCTPP1 1885/4885CNR1 648/4885CNR2 740/4885 |
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | DCTPP1 1173/4885CNR1 4297/4885CNR2 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.