Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017205 | 0.82 | CA4 (0.50) | KIF11 | |
| SCHEMBL3932304 | 0.82 | CA4 (0.50) | KIF11 | |
| SCHEMBL9085801 | 0.81 | KCNN4 (0.46) | KIF11KCNN4ALDH1A1TSHRPTPN1 | |
| SCHEMBL8973 | 0.75 | KIF11 (0.48) | KIF11MAPK1KCNN4ALDH1A1TSHR | |
| SCHEMBL297786 | 0.75 | MAPK1 (0.52) | KIF11MAPK1KCNN4ALDH1A1TSHR | |
| Ammonia Solution, Strong SCHEMBL23726528 | 0.73 | KIF11 (0.46) | KIF11MAPK1KCNN4ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL28556207 | 0.73 | KIF11 (0.46) | KIF11MAPK1KCNN4ALDH1A1TSHR | |
| Bromide SCHEMBL28557682 | 0.73 | KIF11 (0.46) | KIF11MAPK1KCNN4ALDH1A1TSHR | |
| SCHEMBL15093614 | 0.72 | MAPK1 (0.64) | MAPK1KCNN4ALDH1A1TSHRALOX15 | |
| SCHEMBL7201481 | 0.72 | TSHR (0.50) | KIF11MAPK1KCNN4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 904 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962858-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-02-24 | — | — | US | claimed |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2014-10-16 | — | — | US | claimed |
| EP-2665716-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2013-11-27 | — | — | EP | claimed |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-01 | — | — | US | claimed |
| US-8426584-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-23 | — | — | US | claimed |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | claimed |
| WO-2012100179-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | WO | claimed |
| EP-1660450-A4 | MONOMERS, OLIGOMERS AND POLYMERS OF 2-FUNCTIONALIZED AND 2,7-DIFUNCTIONALIZED CARBAZOLES | UNIV LAVAL (CA) | 2009-07-29 | — | — | EP | claimed |
| US-20080177108-A1 | Phenyloxyaniline derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-07-24 | — | — | US | claimed |
| US-20080170993-A1 | THYMIDINE ANALOGS FOR IMAGING | BAYER SCHERING PHARMA AG (DE) | 2008-07-17 | — | — | US | claimed |
| WO-2005016882-A1 | MONOMERS, OLIGOMERS AND POLYMERS OF 2-FUNCTIONALIZED AND 2,7-DIFUNCTIONALIZED CARBAZOLES | UNIVERSITE LAVAL (CA) | 2005-02-24 | — | — | WO | claimed |
| WO-2004064745-A2 | METHOD OF PREPARATION OF HETEROCYCLIC MOLECULES WITH PHARMACEUTICAL PHARMACEUTICAL EXCIPIENT COSMECEUTICAL AGROCHEMICAL AND INDUSTRIAL USES | AUSPEX PHARMACEUTICALS, INC. (US) | 2004-08-05 | — | — | WO | claimed |
| EP-0999204-A1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-10 | — | — | EP | claimed |
| US-5554757-A | Process for the preparation of imidazopyridine derivatives, and intermediates therefore | EISAI CO., LTD. (JP) | 1996-09-10 | — | — | US | claimed |
| EP-0436157-B1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-23 | — | — | EP | claimed |
| EP-0627433-A1 | PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE | Eisai Co., Ltd. (JP) | 1994-12-07 | — | — | EP | claimed |
| US-5296487-A | Dopamine antagonist for nervous system disorders | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | claimed |
| US-5264438-A | Dopamine receptor agonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | claimed |
| EP-0436157-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-10 | — | — | EP | claimed |
| EP-0235796-A2 | Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1987-09-09 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | KIF11 4773/4885MAPK1 4366/4885KCNN4 4504/4885 |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | KIF11 4773/4885MAPK1 4366/4885KCNN4 4504/4885 |
| US-20080170993-A1 | THYMIDINE ANALOGS FOR IMAGING | TK1, TYMP, TK2 | KIF11 957/4885MAPK1 1590/4885KCNN4 4240/4885 |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | KIF11 4773/4885MAPK1 4366/4885KCNN4 4504/4885 |
| US-20080177108-A1 | Phenyloxyaniline derivatives | PNMT, PAH, NAT1 | KIF11 4498/4885MAPK1 1981/4885KCNN4 2940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.