Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 1/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 4/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161561 | 0.88 | MAPK1 (0.80) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL6585695 | 0.87 | MAPK1 (0.78) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL6159635 | 0.86 | MAPK1 (1.00) | MAPK1MAPTPKMRAB9ANPSR1 | |
| Hydrochloric Acid SCHEMBL11102389 | 0.85 | MAPK1 (0.97) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL3604839 | 0.84 | MAPK1 (0.74) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL7240975 | 0.83 | MAPK1 (0.54) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL7240972 | 0.83 | MAPK1 (0.54) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL2090303 | 0.82 | MAPK1 (0.78) | MAPK1MAPTPKMRAB9ANPSR1 | |
| SCHEMBL2978252 | 0.81 | SIGMAR1 (0.63) | L3MBTL1SIGMAR1POLBSLC6A12TMEM97 | |
| SCHEMBL8884292 | 0.81 | MAPK1 (0.77) | MAPK1MAPTPKMRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723360-B2 | Alkyl-and piperidine-substituted benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| US-7723360-B2 | Alkyl-and piperidine-substituted benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| US-7723360-B2 | Alkyl-and piperidine-substituted benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| EP-1776356-B1 | ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES | BOEHRINGER INGELHEIM INT (DE) | 2008-09-17 | — | — | EP | disclosed |
| EP-1776356-B1 | ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES | BOEHRINGER INGELHEIM INT (DE) | 2008-09-17 | — | — | EP | disclosed |
| EP-1776356-A1 | ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-04-25 | — | — | EP | disclosed |
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| EP-1660476-B1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2006-12-27 | — | — | EP | disclosed |
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| EP-1660476-A1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2006013073-A1 | ALKYL-AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-09 | — | — | WO | disclosed |
| US-20060030590-A1 | Alkyl-and piperidine-substituted benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-09 | — | — | US | disclosed |
| US-20050124659-A1 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| WO-2005019203-A1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-03-03 | — | — | WO | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124659-A1 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | ABCB11, KCNJ11, CFTR | MAPK1 3680/4885MAPT 3911/4885PKM 374/4885 |
| US-20060030590-A1 | Alkyl-and piperidine-substituted benzimidazole derivatives | ABCB11, KCNJ11, ABCB1 | MAPK1 2465/4885MAPT 3369/4885PKM 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.