Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261039 | 0.77 | HTT (0.38) | ALOX15 | |
| SCHEMBL2996821 | 0.74 | ALDH1A1 (0.36) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL269884 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL584784 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL558535 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL641339 | 0.69 | ALDH1A1 (0.47) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL7060124 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL558480 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL521935 | 0.69 | NQO2 (0.46) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL2994886 | 0.69 | ACP1 (0.37) | CTSKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829466-B2 | Stilbene derivative and preparation method thereof | BEIJING INSTITUTE OF TECHNOLOGY (CN) | 2020-11-10 | — | — | US | claimed |
| US-20200148662-A1 | NOVEL STILBENE DERIVATIVE AND PREPARATION METHOD THEREOF | BEIJING INSTITUTE OF TECHNOLOGY (CN) | 2020-05-14 | — | — | US | claimed |
| US-9879004-B2 | Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2018-01-30 | — | — | US | claimed |
| US-20150376182-A1 | Substituted Acetylene Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | claimed |
| US-8900725-B2 | Dendrimer and organic light-emitting device using the same | SAMSUNG DISPLAY CO., LTD. | 2014-12-02 | — | — | US | claimed |
| US-8865322-B2 | Dendrimer and organic light-emitting device using the same | SAMSUNG DISPLAY CO., LTD. (KR) | 2014-10-21 | — | — | US | claimed |
| EP-2407501-B1 | Dendrimer and organic light-emitting device using the same | SAMSUNG DISPLAY CO LTD (KR) | 2013-09-11 | — | — | EP | claimed |
| EP-2407502-B1 | Dendrimer and organic light-emitting device using the same | SAMSUNG DISPLAY CO LTD (KR) | 2013-06-19 | — | — | EP | claimed |
| US-20120013246-A1 | DENDRIMER AND ORGANIC LIGHT-EMITTING DEVICE USING THE SAME | SAMSUNG MOBILE DISPLAY CO., LTD. (KR) | 2012-01-19 | — | — | US | claimed |
| US-20120013247-A1 | DENDRIMER AND ORGANIC LIGHT-EMITTING DEVICE USING THE SAME | SAMSUNG MOBILE DISPLAY CO., LTD. (KR) | 2012-01-19 | — | — | US | claimed |
| JP-2007512280-A | — | — | 2007-05-17 | — | — | JP | claimed |
| US-7217711-B2 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-15 | — | — | US | claimed |
| EP-1742949-A1 | NOVEL-2-(PIPERAZIN-1-YL)-AND-2-([1,4]DIAZEPAN-1-YL)-IMIDAZO[4,5-D]PYRIDAZIN-4-ONE, PRODUCTION AND USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF DIABETES MELLITUS | Boehringer Ingelheim International GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| EP-1689748-A1 | NOVEL 8-(PIPERAZINE-1-YL)- AND 8-( 1,4|DIAZEPAN-1-YL)-XANTHINE, THE PRODUCTION AND USE THEREOF IN THE FROM OF A DRUG | Boehringer Ingelheim International GmbH (DE) | 2006-08-16 | — | — | EP | claimed |
| US-20050171093-A1 | New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-08-04 | — | — | US | claimed |
| WO-2005058901-A1 | NOVEL 2-(PIPERAZIN-1-YL)- AND 2-([1,4]DIAZEPAN-1-YL)- IMIDAZO[4,5-D]PYRIDAZIN-4-ONE, PRODUCTION AND USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF DIABETES MELLITUS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-30 | — | — | WO | claimed |
| US-20050130985-A1 | 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-16 | — | — | US | claimed |
| WO-2005051950-A1 | NOVEL 8-(PIPERAZINE-1-YL)- AND 8-([1,4]DIAZEPAN-1-YL)-XANTHINE, THE PRODUCTION AND USE THEREOF IN THE FROM OF A DRUG | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-09 | — | — | WO | claimed |
| EP-0715626-A1 | ANTIMICROBIAL QUINOLINYL-(1H-1,2,4-TRIAZOL-1-YL)ALKANOL DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-12 | — | — | EP | claimed |
| WO-1995006047-A1 | ANTIMICROBIAL QUINOLINYL-(1H-1,2,4-TRIAZOL-1-YL)ALKANOL DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171093-A1 | New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions | DPP4, DPP3, DPP7 | ALDH1A1 285/4885KDM4E 844/4885GAA 211/4885 |
| US-20050130985-A1 | 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition | DPP8, DPP4, DPP7 | ALDH1A1 247/4885KDM4E 1514/4885GAA 295/4885 |
| US-20120013247-A1 | DENDRIMER AND ORGANIC LIGHT-EMITTING DEVICE USING THE SAME | CLTB, CD40LG, DYNLL2 | ALDH1A1 768/4885KDM4E 3262/4885GAA 2601/4885 |
| US-20150376182-A1 | Substituted Acetylene Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | GRM4, GRIA4, GRIK4 | ALDH1A1 3648/4885KDM4E 609/4885GAA 4476/4885 |
| US-10829466-B2 | Stilbene derivative and preparation method thereof | STS, F12, GLB1 | ALDH1A1 449/4885KDM4E 4389/4885GAA 2194/4885 |
| US-20120013246-A1 | DENDRIMER AND ORGANIC LIGHT-EMITTING DEVICE USING THE SAME | CLTB, CD40LG, DYNLL2 | ALDH1A1 768/4885KDM4E 3262/4885GAA 2601/4885 |
| US-20200148662-A1 | NOVEL STILBENE DERIVATIVE AND PREPARATION METHOD THEREOF | STS, F12, STK38L | ALDH1A1 415/4885KDM4E 4442/4885GAA 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.