Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144228 | 0.95 | EPHX2 (0.45) | EPHX2CYP2C9CYP2C19NTRK1KCNH2 | |
| SCHEMBL5142098 | 0.94 | KMT2A (0.45) | EPHX2CYP2C9CYP2C19NTRK1KCNH2 | |
| SCHEMBL4074904 | 0.90 | EPHX2 (0.49) | EPHX2FAAHCYP2C9CYP2C19NTRK1 | |
| SCHEMBL3290058 | 0.89 | CFD (0.42) | EPHX2NR1H4CYP2C9NTRK1KCNH2 | |
| SCHEMBL5145627 | 0.88 | EPHX2 (0.43) | EPHX2CYP2C9PRKAA2CFD | |
| SCHEMBL3289653 | 0.87 | EPHX2 (0.42) | EPHX2FAAHCYP2C9PRKAA2CFD | |
| SCHEMBL5298159 | 0.86 | MAPT (0.44) | PRKAA2POLB | |
| SCHEMBL3288509 | 0.86 | NTRK1 (0.50) | EPHX2CYP2C9CYP2C19NTRK1KCNH2 | |
| SCHEMBL3295798 | 0.85 | SLC5A7 (0.44) | EPHX2CYP2C9PRKAA2CFD | |
| SCHEMBL5143816 | 0.85 | PRKAA2 (0.41) | PRKAA2CFDSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723358-B2 | Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems | MERCK PATENT GMBH (DE) | 2010-05-25 | — | — | US | claimed |