Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | APOB | P04114 | 2/20 | 0.40 |
| ▸ | MTTP | P55157 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3295205 | 0.91 | MAPT (0.50) | MAPTPOLBTHRBRXFP1GPR119 | |
| SCHEMBL5144228 | 0.90 | EPHX2 (0.45) | POLB | |
| SCHEMBL5143816 | 0.89 | PRKAA2 (0.41) | PRKAA2 | |
| SCHEMBL3289635 | 0.88 | APOB (0.48) | MAPTPOLBRXFP1TP53GPR119 | |
| SCHEMBL5145627 | 0.87 | EPHX2 (0.43) | PRKAA2 | |
| SCHEMBL5142098 | 0.87 | KMT2A (0.45) | POLBPRKAA2 | |
| SCHEMBL5144180 | 0.86 | PRKAA2 (0.41) | MAPTPOLBPRKAA2 | |
| SCHEMBL3289653 | 0.86 | EPHX2 (0.42) | PRKAA2 | |
| SCHEMBL3290058 | 0.86 | CFD (0.42) | RXFP1 | |
| SCHEMBL3289992 | 0.86 | EPHX2 (0.46) | POLBPRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753721-A1 | AROYL-O-PIPERIDINE DERIVATIVES FOR THE TREATMENT OF DIABETES-RELATED PROBLEMS | MERCK PATENT GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005121091-A1 | AROYL-O-PIPERIDINE DERIVATIVES FOR THE TREATMENT OF DIABETES-RELATED PROBLEMS | MERCK PATENT GMBH (DE) | 2005-12-22 | — | — | WO | disclosed |