Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.63 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.63 |
| ▸ | CASP7 | P55210 | 2/20 | 0.63 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rhein SCHEMBL5712169 | 0.93 | TTR (0.58) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5712176 | 0.85 | TTR (0.48) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL971641 | 0.82 | KMT2A (0.60) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL3292601 | 0.80 | TTR (0.72) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL9279787 | 0.78 | TTR (0.77) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL23655432 | 0.78 | TTR (0.84) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| Diacerein SCHEMBL29423907 | 0.78 | TTR (1.00) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| Diacerein SCHEMBL29944894 | 0.78 | TTR (1.00) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| Diacerein SCHEMBL5051685 | 0.78 | TTR (1.00) | TTRALDH1A1MAPTLMNASMN1; SMN2 | |
| Diacerein SCHEMBL25784 | 0.78 | TTR (1.00) | TTRALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728035-B2 | Ester derivatives of rhein and their therapeutic use | SOSEI R&D LTD. (GB) | 2010-06-01 | — | — | US | claimed |
| US-20070185036-A1 | Ester derivatives of rhein and their therapeutic use | SOSEI R&D LTD (GB) | 2007-08-09 | — | — | US | claimed |
| EP-1723097-A1 | ESTER DERIVATIVES OF RHEIN AND THEIR THERAPEUTIC USE | Sosei R&D Ltd. (GB) | 2006-11-22 | — | — | EP | claimed |
| WO-2005085170-A1 | ESTER DERIVATIVES OF RHEIN AND THEIR THERAPEUTIC USE | SOSEI R&D LTD. (GB) | 2005-09-15 | — | — | WO | claimed |
| US-7728035-B2 | Ester derivatives of rhein and their therapeutic use | SOSEI R&D LTD. (GB) | 2010-06-01 | — | — | US | disclosed |
| US-20070185036-A1 | Ester derivatives of rhein and their therapeutic use | SOSEI R&D LTD (GB) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185036-A1 | Ester derivatives of rhein and their therapeutic use | RCOR1, RCOR3, OXER1 | TTR 4254/4885ALDH1A1 3680/4885MAPT 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.