Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339898 | 1.00 | CYP19A1 (0.63) | CYP19A1HTTCYSLTR2CYSLTR1TDP1 | |
| SCHEMBL3296474 | 1.00 | CYP19A1 (0.63) | CYP19A1HTTCYSLTR2CYSLTR1TDP1 | |
| SCHEMBL4800134 | 0.98 | CYP19A1 (0.61) | CYP19A1HTTCYSLTR2CYSLTR1TDP1 | |
| SCHEMBL4378454 | 0.94 | HTT (0.61) | CYP19A1HTTTDP1MAPTALDH1A1 | |
| SCHEMBL11220987 | 0.91 | HTT (0.64) | CYP19A1HTTTDP1MAPTALDH1A1 | |
| SCHEMBL3294199 | 0.89 | HTT (0.63) | CYP19A1HTTTDP1MAPTALDH1A1 | |
| SCHEMBL8977128 | 0.88 | TDP1 (0.60) | CYP19A1HTTCYSLTR2CYSLTR1TDP1 | |
| SCHEMBL9127581 | 0.88 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL1609478 | 0.88 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE | |
| SCHEMBL9165752 | 0.88 | CYP19A1 (0.66) | CYP19A1CYSLTR2CYSLTR1CNR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741520-B2 | Sulfonanilide analogs as selective aromatase modulators (SAMs) | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1984325-A2 | SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20080045598-A1 | Novel sulfonanilide analogs as selective aromatase modulators (SAMs) | THE OHIO STATE UNIVERSITY (US) | 2008-02-21 | — | — | US | disclosed |
| WO-2007120379-A2 | SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045598-A1 | Novel sulfonanilide analogs as selective aromatase modulators (SAMs) | CYP19A1, AR, SULT2A1 | CYP19A1 1/4885HTT 3747/4885CYSLTR2 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.