SCHEMBL3293262

SCHEMBL3293262

O=c1ncc2ccccc2n1-c1ccsc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.35
PDGFRB P09619 1/20 0.35
PDGFRA P16234 1/20 0.35
HCAR1 Q9BXC0 1/20 0.35
ADORA2A P29274 1/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
HSD11B1 P28845 1/20 0.32
HTR3A P46098 1/20 0.32
KDM4E B2RXH2 1/20 0.32
KMT2A Q03164 1/20 0.32
PDE1B Q01064 1/20 0.31
PDE3A Q14432 1/20 0.31
PDE11A Q9HCR9 1/20 0.31
NOTUM Q6P988 1/20 0.31
AURKA O14965 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12628244 0.80 ALDH1A1 (0.46) GAAKDM4EKMT2APDE1BPDE3A
SCHEMBL28196196 0.70 NOTUM (0.40) PDGFRBPDGFRANOTUMALDH1A1TSHR
SCHEMBL28195486 0.70 MAPT (0.39) NPC1KDM4EKMT2ANOTUMALDH1A1
SCHEMBL31422985 0.68 PLA2G10 (0.40) GAAKDM4ENOTUMALDH1A1TSHR
SCHEMBL24462505 0.68 KDM4E (0.56) NPC1KDM4EKMT2AALDH1A1
SCHEMBL7738629 0.66 NOS2 (0.38) NPC1KDM4EKMT2AALDH1A1
SCHEMBL7613241 0.66 KDM4E (0.43) KDM4EKMT2AALDH1A1
SCHEMBL30738537 0.66 CA12 (0.34) HTR3AKDM4EKMT2ANOTUMALDH1A1
SCHEMBL8229991 0.66 CA12 (0.52) GAAKDM4EKMT2APDE3AALDH1A1
SCHEMBL30692889 0.66 CA12 (0.52) GAAKDM4EKMT2APDE3AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004098612-A2 CALCITRIOL ANALOGS OF USES THEREOF AB SCIENCE (FR) 2004-11-18 WO claimed
US-9545410-B2 Tyrosine kinase inhibitors as anti-kinetoplastid agents UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2017-01-17 US disclosed
US-20130072484-A1 TYROSINE KINASE INHIBITORS AS ANTI-KINETOPLASTID AND ANTI-APICOMPLEXAN AGENTS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2013-03-21 US disclosed
US-8338433-B2 Tyrosine kinase inhibitors as anti-kinetoplastid agents UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2012-12-25 US disclosed
US-20100311742-A1 TYROSINE KINASE INHIBITORS AS ANTI-KINETOLASTID AND ANTI-APICOMPLEXAN AGENTS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2010-12-09 US disclosed
US-7741335-B2 Use of tyrosine kinase inhibitors for treating inflammatory diseases AB SCIENCE (FR) 2010-06-22 US disclosed
US-7727731-B2 Potent, selective and non toxic c-kit inhibitors AB SCIENCE (FR) 2010-06-01 US disclosed
US-7700610-B2 Use of tyrosine kinase inhibitors for treating allergic diseases AB SCIENCE (FR) 2010-04-20 US disclosed
US-7678805-B2 Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD) AB SCIENCE (FR) 2010-03-16 US disclosed
EP-2088863-A2 TYROSINE KINASE INHIBITORS AS ANTI-KINETOLASTID AND ANTI-APICOMPLEXAN AGENTS University Of Georgia Research Foundation, Inc. (US) 2009-08-19 EP disclosed
WO-2003035049-A2 USE OF POTENT, SELECTIVE AND NON-TOXIC C-KIT INHIBITORS FOR TREATING BACTERIAL INFECTIONS AB SCIENCE (FR) 2003-05-01 WO disclosed
WO-2003024386-A2 USE OF POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS FOR TREATING INTERSTITIAL CYSTITIS AB SCIENCE (FR) 2003-03-27 WO disclosed
WO-2003004006-A2 USE OF POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS FOR TREATING TUMOR ANGIOGENESIS AB SCIENCE (FR) 2003-01-16 WO disclosed
WO-2003004007-A2 USE OF TYROSINE KINASE INHIBITORS FOR TREATING INFLAMMATORY BOWEL DISEASES (IBD) AB SCIENCE (FR) 2003-01-16 WO disclosed
WO-2003002109-A2 USE OF TYROSINE KINASE INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AB SCIENCE (FR) 2003-01-09 WO disclosed
WO-2003002107-A2 USE OF TYROSINE KINASE INHIBITORS FOR TREATING MULTIPLE SCLEROSIS (MS) AB SCIENCE (FR) 2003-01-09 WO disclosed
WO-2003002108-A2 USE OF TYROSINE KINASE INHIBITORS FOR TREATING INFLAMMATORY DISEASES AB SCIENCE (FR) 2003-01-09 WO disclosed
WO-2003003006-A2 NEW POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS AB SCIENCE (FR) 2003-01-09 WO disclosed
WO-2003002114-A2 USE OF POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS FOR TREATING MASTOCYTOSIS AB SCIENCE (FR) 2003-01-09 WO disclosed
WO-2003002106-A2 USE OF TYROSINE KINASE INHIBITIONS FOR TREATING ALLERGIC DISEASES AB SCIENCE (FR) 2003-01-09 WO disclosed