Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103338 | 0.84 | — | — | |
| SCHEMBL20567319 | 0.76 | AR (0.42) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL526351 | 0.76 | ALDH1A1 (0.50) | ALDH1A1TDP1MEN1NPC1POLB | |
| SCHEMBL329657 | 0.75 | MAPK1 (0.40) | TDP1CYP3A4MAPK1 | |
| SCHEMBL9033428 | 0.71 | IMPDH2 (0.31) | IMPDH2 | |
| SCHEMBL9712590 | 0.70 | AR (0.36) | CYP3A4ALOX15 | |
| SCHEMBL6146245 | 0.70 | TSHR (0.52) | ALDH1A1TDP1MEN1POLBMAPT | |
| SCHEMBL9311176 | 0.70 | CYP3A4 (0.31) | TDP1CYP3A4TSHRMAPK1 | |
| SCHEMBL104772 | 0.69 | CYP3A4 (0.32) | ALDH1A1TDP1MEN1KMT2ACYP3A4 | |
| SCHEMBL103590 | 0.67 | MAPK1 (0.30) | TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487095-B1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5286736-A | Thromboxane antagonists and thromboxane synthetase inhibitors | DR. KARL THOMAE GMBH (DE) | 1994-02-15 | — | — | US | disclosed |
| EP-0487095-A1 | Pyridyl derivatives, medicines containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-05-27 | — | — | EP | disclosed |