Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.77 |
| ▸ | PPARG | P37231 | 6/20 | 0.73 |
| ▸ | PPARD | Q03181 | 5/20 | 0.73 |
| ▸ | PPARA | Q07869 | 5/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.73 |
| ▸ | FABP4 | P15090 | 4/20 | 0.73 |
| ▸ | TERT | O14746 | 3/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | BLM | P54132 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.73 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.73 |
| ▸ | F7 | P08709 | 3/20 | 0.73 |
| ▸ | F3 | P13726 | 3/20 | 0.73 |
| ▸ | USP2 | O75604 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4933043 | 1.00 | TOP1 (0.77) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL14227099 | 1.00 | TOP1 (0.77) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL3299485 | 1.00 | TOP1 (0.77) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL4651892 | 1.00 | TOP1 (0.77) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL14227104 | 1.00 | TOP1 (0.77) | TOP1PPARGPPARDPPARAHSD17B10 | |
| Oleic Acid SCHEMBL25336982 | 0.97 | PPARG (0.79) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL16320281 | 0.97 | PPARG (0.79) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL10482039 | 0.97 | PPARG (0.73) | TOP1PPARGPPARDPPARAHSD17B10 | |
| Stearic Acid SCHEMBL7615219 | 0.97 | PPARG (0.79) | TOP1PPARGPPARDPPARAHSD17B10 | |
| SCHEMBL14224922 | 0.97 | PPARG (0.79) | TOP1PPARGPPARDPPARAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550617-B2 | Compositions and methods for the treatment of renal and cardiovascular disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) | 2009-06-23 | — | — | US | claimed |
| US-20080146663-A1 | Compositions and Methods for the Treatment of Renal and Cardiovascular Disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE | 2008-06-19 | — | — | US | claimed |
| US-7732470-B2 | Compositions and methods for the treatment of renal and cardiovascular disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) | 2010-06-08 | — | — | US | disclosed |
| US-7550617-B2 | Compositions and methods for the treatment of renal and cardiovascular disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080153889-A1 | Compositions and Methods for the Treatment of Renal and Cardiovascular Disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE | 2008-06-26 | — | — | US | disclosed |
| US-20080146663-A1 | Compositions and Methods for the Treatment of Renal and Cardiovascular Disease | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153889-A1 | Compositions and Methods for the Treatment of Renal and Cardiovascular Disease | REN, ALOX5, ALOX15B | TOP1 2007/4885PPARG 240/4885PPARD 520/4885 |
| US-20080146663-A1 | Compositions and Methods for the Treatment of Renal and Cardiovascular Disease | REN, ALOX5, ALOX15B | TOP1 2051/4885PPARG 240/4885PPARD 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.