SCHEMBL3299595

SCHEMBL3299595

COc1c(C)cccc1[SiH](O[SiH](c1ccccc1)c1cccc(C)c1OC)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN4A P35499 9/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
POLB P06746 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPK1 P28482 2/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
SCN8A Q9UQD0 2/20 0.33
LMNA P02545 2/20 0.33
SCN1A P35498 2/20 0.33
SCN5A Q14524 2/20 0.33
SCN9A Q15858 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3299989 0.87 ALDH1A1 (0.34) SCN4APOLBSMN1; SMN2KDM4EALDH1A1
SCHEMBL3297598 0.83 NFE2L2 (0.42) L3MBTL1SMN1; SMN2KDM4EALDH1A1MAPK1
SCHEMBL3297946 0.81 ACHE (0.38) SCN4AL3MBTL1KDM4EALDH1A1LMNA
SCHEMBL3296746 0.76 CA1 (0.40) L3MBTL1POLBSMN1; SMN2KDM4EALDH1A1
SCHEMBL3296357 0.74 CA1 (0.46) L3MBTL1POLBSMN1; SMN2ALDH1A1MAPK1
SCHEMBL6672387 0.74 ALDH1A1 (0.36) SCN4ASMN1; SMN2KDM4EALDH1A1MAPK1
SCHEMBL3295192 0.72 CA1 (0.40) L3MBTL1POLBKDM4EALDH1A1MAPK1
SCHEMBL28753767 0.72 ACHE (0.36) SCN4AL3MBTL1KDM4EALDH1A1TSHR
SCHEMBL3301594 0.71 GAA (0.45) L3MBTL1POLBSMN1; SMN2KDM4EALDH1A1
SCHEMBL3295482 0.71 GAA (0.41) L3MBTL1POLBSMN1; SMN2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7741393-B2 Organic silicon-based compound and method of producing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-22 US disclosed
US-20070203275-A1 Organic Silicon-Based Compound And Method Of Producing The Same SUMITOMO CHEMICAL COMPANY, LIMITED 2007-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203275-A1 Organic Silicon-Based Compound And Method Of Producing The Same ARSA, OR10J3, HDAC10 SCN4A 1510/4885L3MBTL1 1173/4885POLB 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.