Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 6/20 | 0.37 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL330199 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL330677 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL10947939 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL7815097 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL17225894 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL330198 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL10795468 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL416772 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL10947943 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL7815100 | 1.00 | TSHR (0.44) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384191-B1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2018-07-18 | — | — | EP | disclosed |
| EP-2373302-B1 | THE USE OF COMPOUNDS TO INHIBIT 5alpha-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2017-09-13 | — | — | EP | disclosed |
| US-9668984-B2 | Use of compounds to inhibit 5 α-reductase enzyme activity, and pharmaceutical and cosmetic compostions containing them | GIULIANI S.P.A. (IT) | 2017-06-06 | — | — | US | disclosed |
| US-9597295-B2 | Diene compounds for use in human epidermal cell repair, and pharmaceutical and cosmetic compositions containing them | GIULIANI S.P.A. (IT) | 2017-03-21 | — | — | US | disclosed |
| EP-2593097-B1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2016-08-24 | — | — | EP | disclosed |
| US-9289405-B2 | Compounds provided with antioxidant activity against free radicals, and pharmaceutical and cosmetic compositions containing them | GIULIANI S.P.A (IT) | 2016-03-22 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
| EP-2560632-B1 | COMPOUNDS PROVIDED WITH ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS, AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2014-10-29 | — | — | EP | disclosed |
| US-20130150443-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2013-06-13 | — | — | US | disclosed |
| US-20130046017-A1 | COMPOUNDS PROVIDED WITH ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2013-02-21 | — | — | US | disclosed |
| EP-2407163-A1 | Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them | Giuliani S.p.A. (IT) | 2012-01-18 | — | — | EP | disclosed |
| EP-2384191-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Giuliani S.p.A. (IT) | 2011-11-09 | — | — | EP | disclosed |
| WO-2011132177-A1 | COMPOUNDS PROVIDED WITH ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2011-10-27 | — | — | WO | disclosed |
| EP-2373302-A1 | THE USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Giuliani S.p.A. (IT) | 2011-10-12 | — | — | EP | disclosed |
| US-20110224298-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2011-09-15 | — | — | US | disclosed |
| US-20110218245-A1 | USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2011-09-08 | — | — | US | disclosed |
| WO-2010052329-A1 | THE USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052328-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218245-A1 | USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | SRD5A1, CYP17A1, SRD5A2 | TSHR 1843/4885TP53 3542/4885EGLN1 1409/4885 |
| US-20110224298-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | KRT18, CKS2, MKI67 | TSHR 3293/4885TP53 89/4885EGLN1 2605/4885 |
| US-20130046017-A1 | COMPOUNDS PROVIDED WITH ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | LPO, CAT, TYR | TSHR 1720/4885TP53 2683/4885EGLN1 932/4885 |
| US-20130150443-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | KRT18, MMS19, CKS2 | TSHR 3140/4885TP53 84/4885EGLN1 2906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.