Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 1.00 |
| ▸ | BRD4 | O60885 | 5/20 | 0.79 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.79 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.73 |
| ▸ | PRKCB | P05771 | 1/20 | 0.73 |
| ▸ | PRKCA | P17252 | 1/20 | 0.73 |
| ▸ | PRKACA | P17612 | 1/20 | 0.73 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.73 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.73 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.73 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943872 | 0.95 | MAPK14 (1.00) | MAPK14BRD4BRDTMAPK11PRKD3 | |
| SCHEMBL6950475 | 0.91 | MAPK14 (1.00) | MAPK14BRD4BRDTMAPK11PRKD3 | |
| SCHEMBL7815820 | 0.90 | MAPK14 (0.91) | MAPK14BRD4BRDTMAPK11 | |
| SCHEMBL6955254 | 0.90 | MAPK14 (0.81) | MAPK14BRD4BRDTMAPK11 | |
| SCHEMBL6943778 | 0.89 | MAPK14 (1.00) | MAPK14BRD4BRDT | |
| Trifluoroacetic Acid SCHEMBL6948788 | 0.88 | MAPK14 (0.87) | MAPK14BRD4BRDTMAPK11 | |
| SCHEMBL6946459 | 0.88 | MAPK14 (0.79) | MAPK14BRD4BRDTMAPK11 | |
| SCHEMBL6948107 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDTMAPK11PRKD3 | |
| SCHEMBL6943923 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDT | |
| SCHEMBL6950953 | 0.86 | MAPK14 (1.00) | MAPK14BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086641-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR THE TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008049842-A2 | EGFR KINASE INHIBITOR COMBINATIONS FOR THE TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-02 | — | — | WO | claimed |
| US-20100099651-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | US | disclosed |
| US-20080108658-A1 | METHODS OF PROMOTING OSTEOGENESIS | PROTTER ANDREW A | 2008-05-08 | — | — | US | disclosed |
| US-20080108658-A1 | METHODS OF PROMOTING OSTEOGENESIS | PROTTER ANDREW A | 2008-05-08 | — | — | US | disclosed |
| US-20080039461-A1 | Treatment of pain by inhibition of p38 map kinase | PROTTER ANDREW A | 2008-02-14 | — | — | US | disclosed |
| US-20080039461-A1 | Treatment of pain by inhibition of p38 map kinase | PROTTER ANDREW A | 2008-02-14 | — | — | US | disclosed |
| US-7244441-B2 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244441-B2 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099651-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS | BDKRB2, GRK5, PRKCH | MAPK14 71/4885BRD4 2119/4885BRDT 2461/4885 |
| US-20080108658-A1 | METHODS OF PROMOTING OSTEOGENESIS | MAPK1, BMP2, MAPK3 | MAPK14 23/4885BRD4 1516/4885BRDT 2959/4885 |
| US-20080039461-A1 | Treatment of pain by inhibition of p38 map kinase | OPRK1, OPRL1, MAPK3 | MAPK14 36/4885BRD4 3147/4885BRDT 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.