Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3297395 | 0.78 | ALB (0.46) | LMNAALBPOLG | |
| SCHEMBL13843601 | 0.77 | LMNA (0.52) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL9921154 | 0.75 | LMNA (0.47) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL24337513 | 0.74 | LMNA (0.62) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14929500 | 0.74 | LMNA (0.59) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL10015807 | 0.74 | LMNA (0.59) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14946352 | 0.73 | LMNA (0.39) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL8886244 | 0.73 | LMNA (0.72) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL800596 | 0.73 | LMNA (0.48) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17750141 | 0.73 | LMNA (0.57) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361988-B2 | Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2013-01-29 | — | — | US | disclosed |
| US-20100093737-A1 | Nucleoside and Nucleotide Analogues with Quaternary Carbon Centers and Methods of Use | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093737-A1 | Nucleoside and Nucleotide Analogues with Quaternary Carbon Centers and Methods of Use | NUDT1, NT5C3B, NTPCR | LMNA 1497/4885THRB 4527/4885MTOR 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.