Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28447659 | 0.86 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12376670 | 0.84 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL5099185 | 0.82 | MME (0.54) | ALDH1A1PTPRCPTPN1 | |
| SCHEMBL12848458 | 0.82 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5099195 | 0.82 | MME (0.54) | ALDH1A1PTPRCPTPN1 | |
| SCHEMBL8247495 | 0.81 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL8003960 | 0.81 | CSNK1D (0.50) | ALDH1A1PTPRCPTPN1SMN1; SMN2CSNK1D | |
| SCHEMBL3301528 | 0.80 | TSHR (0.45) | ALDH1A1NPC1MAPTTSHR | |
| SCHEMBL9417473 | 0.80 | GPR34 (0.62) | — | |
| SCHEMBL6963806 | 0.80 | ATM (0.51) | PTPRCPTPN1SMN1; SMN2CSNK1DADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224224-B2 | Thiobenzoimidazole as fungicides | REDAG CROP PROTECTION LTD. (GB) | 2022-01-18 | — | — | US | disclosed |
| US-20210206744-A1 | BENZIMIDAZOLE COMPOUNDS AS AGRICULTURAL CHEMICALS | REDAG CROP PROT LTD (GB) | 2021-07-08 | — | — | US | disclosed |
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | GAUDINO JOHN | 2011-03-03 | — | — | US | disclosed |
| US-7879839-B2 | For treatment and prevention of cardiac arrhythmias; (+-)-2-Morpholin-4-yl-2-phenyl-1,1-dipyridin-3-yl-ethanol; (+-)-2-[(2-methoxyethyl)(methyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol | MERCK SHARP & DOHME CORP. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20100105683-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | KEEGAN KATHLEEN S | 2010-04-29 | — | — | US | disclosed |
| US-20100099725-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2010-04-22 | — | — | US | disclosed |
| US-20100099725-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2010-04-22 | — | — | US | disclosed |
| US-20100099725-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY | 2010-04-22 | — | — | US | disclosed |
| CN-101616900-A | Peroxisome proliferator activated receptor modulators | LILLY CO ELI | 2009-12-30 | — | — | CN | disclosed |
| EP-2129667-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-12-09 | — | — | EP | disclosed |
| US-7608618-B2 | Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1 | ICOS CORPORATION (US) | 2009-10-27 | — | — | US | disclosed |
| WO-2008103574-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-08-28 | — | — | WO | disclosed |
| WO-2008103574-A2 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-08-28 | — | — | WO | disclosed |
| US-20080090794-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME LLC | 2008-04-17 | — | — | US | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105683-A1 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | CHEK1, PCNA, CHEK2 | ALDH1A1 3047/4885PTPRC 3253/4885PTPN1 4470/4885 |
| US-11224224-B2 | Thiobenzoimidazole as fungicides | CYP1B1, CYP51A1, CYP1A2 | ALDH1A1 280/4885PTPRC 732/4885PTPN1 220/4885 |
| US-20080090794-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | ALDH1A1 2989/4885PTPRC 3258/4885PTPN1 3783/4885 |
| US-20210206744-A1 | BENZIMIDAZOLE COMPOUNDS AS AGRICULTURAL CHEMICALS | BRI3BP, CYP3A4, CYP3A5 | ALDH1A1 420/4885PTPRC 2295/4885PTPN1 4311/4885 |
| US-20110053931-A1 | QUINOLINE COMPOUNDS AND METHODS OF USE | TK1, ABL1, ROR1 | ALDH1A1 1526/4885PTPRC 1313/4885PTPN1 522/4885 |
| US-20100099725-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | PPARA, PPARG, PPARD | ALDH1A1 1161/4885PTPRC 1067/4885PTPN1 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.