Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30876036 | 0.88 | ESR1 (0.61) | ESR1ESR2LMNACYP3A4CYP2C19 | |
| SCHEMBL31371688 | 0.88 | ESR1 (0.61) | ESR1ESR2LMNACYP3A4CYP2C19 | |
| SCHEMBL311076 | 0.88 | ESR1 (0.61) | ESR1ESR2LMNACYP3A4CYP2C19 | |
| SCHEMBL20345259 | 0.84 | ESR1 (0.52) | ESR1ESR2LTA4HCYP3A4CYP2C19 | |
| SCHEMBL29675199 | 0.83 | CALM1 (0.50) | CALM1IDH1ESR1ESR2LTA4H | |
| SCHEMBL146770 | 0.83 | CALM1 (0.50) | CALM1IDH1ESR1ESR2LTA4H | |
| SCHEMBL4455072 | 0.83 | CALM1 (0.50) | CALM1IDH1ESR1ESR2LTA4H | |
| SCHEMBL29675106 | 0.83 | CALM1 (0.50) | CALM1IDH1ESR1ESR2LTA4H | |
| SCHEMBL2551561 | 0.82 | MAOA (0.48) | CYP3A4CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL23428853 | 0.81 | CALM1 (0.48) | CALM1IDH1ESR1ESR2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492384-B2 | Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-07-23 | — | — | US | claimed |
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-12-31 | — | — | US | claimed |
| US-4460384-A | Process for separating carbon monoxide from a gas mixture | NIPPON STEEL CORPORATION (JP) | 1984-07-17 | — | — | US | claimed |
| JP-4211619-A | — | — | None | — | — | JP | disclosed |
| CN-112851608-B | Catalytic oxidation synthesis method of 2-diaryl methyl benzofuran compound | 浙江工业大学 | 2022-07-15 | — | — | CN | disclosed |
| CN-113943199-A | Method for synthesizing amide compound by taking nitrile and diarylmethane as raw materials | 浙江工业大学 | 2022-01-18 | — | — | CN | disclosed |
| CN-107109090-B | Ink composition and photoelectric conversion element produced using same | 住友化学株式会社 | 2021-10-08 | — | — | CN | disclosed |
| CN-112851608-A | Catalytic oxidation synthesis method of 2-diaryl methyl benzofuran compound | 浙江工业大学 | 2021-05-28 | — | — | CN | disclosed |
| WO-2017100668-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-15 | — | — | WO | disclosed |
| US-20150004484-A1 | ORGANIC ELECTROLYTE AND ORGANIC ELECTROLYTE STORAGE BATTERY | JX NIPPON OIL & ENERGY CORPORATION (JP) | 2015-01-01 | — | — | US | disclosed |
| EP-2797154-A1 | ORGANIC ELECTROLYTE, AND ORGANIC ELECTROLYTE STORAGE BATTERY | JX Nippon Oil & Energy Corporation (JP) | 2014-10-29 | — | — | EP | disclosed |
| EP-2797153-A1 | ORGANIC ELECTROLYTE, AND ORGANIC ELECTROLYTE STORAGE BATTERY | JX Nippon Oil & Energy Corporation (JP) | 2014-10-29 | — | — | EP | disclosed |
| US-8492384-B2 | Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-07-23 | — | — | US | disclosed |
| EP-2540163-A1 | Nematocide N-cyclopropyl-sulfonylamide derivatives | Bayer CropScience AG (DE) | 2013-01-02 | — | — | EP | disclosed |
| US-8299072-B2 | Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-10-30 | — | — | US | disclosed |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-04-15 | — | — | US | disclosed |
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-12-31 | — | — | US | disclosed |
| JP-H04211619-A | DIELECTRIC COMPOSITION COMPRISING BENZYLTOLUENE AND (METHYLBENZYL)XYLENE AS PRINCIPAL COMPONENTS | SOC ATOCHEM | 1992-08-03 | — | — | JP | disclosed |
| US-4460384-A | Process for separating carbon monoxide from a gas mixture | NIPPON STEEL CORPORATION (JP) | 1984-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325979-A1 | NOVEL IMIDAZOLYLALKYLCARBONYL DERIVATIVES AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1B, CACNA1C, ORAI1 | CALM1 143/4885IDH1 2288/4885ESR1 4432/4885 |
| US-20100094006-A1 | NOVEL PYRAZOLYLMETHYLAMINE COMPOUNDS AS CALCIUM CHANNEL MODULATORS AND PREPARATION METHOD THEREOF | CACNA1I, CACNA1C, ORAI1 | CALM1 133/4885IDH1 3535/4885ESR1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.